The Regulation of the Autophagic Network and Its Implications for Human Disease

Jing Yang; Serena Carra; Wei-Guo Zhu; Harm H. Kampinga

doi:10.7150/ijbs.6666

Publication

The Regulation of the Autophagic Network and Its Implications for Human Disease

Yang, J., Carra, S., Zhu, W-G. & Kampinga, H. H., 2013, In : International Journal of Biological Sciences. 9, 10, p. 1121-1133 13 p.

Research output: Contribution to journal › Review article › Academic › peer-review

APA

Yang, J., Carra, S., Zhu, W-G., & Kampinga, H. H. (2013). The Regulation of the Autophagic Network and Its Implications for Human Disease. International Journal of Biological Sciences, 9(10), 1121-1133. https://doi.org/10.7150/ijbs.6666

Author

Yang, Jing ; Carra, Serena ; Zhu, Wei-Guo ; Kampinga, Harm H. / The Regulation of the Autophagic Network and Its Implications for Human Disease. In: International Journal of Biological Sciences. 2013 ; Vol. 9, No. 10. pp. 1121-1133.

Harvard

Yang, J, Carra, S, Zhu, W-G & Kampinga, HH 2013, 'The Regulation of the Autophagic Network and Its Implications for Human Disease', International Journal of Biological Sciences, vol. 9, no. 10, pp. 1121-1133. https://doi.org/10.7150/ijbs.6666

Standard

The Regulation of the Autophagic Network and Its Implications for Human Disease. / Yang, Jing; Carra, Serena; Zhu, Wei-Guo; Kampinga, Harm H.

In: International Journal of Biological Sciences, Vol. 9, No. 10, 2013, p. 1121-1133.

Research output: Contribution to journal › Review article › Academic › peer-review

Vancouver

Yang J, Carra S, Zhu W-G, Kampinga HH. The Regulation of the Autophagic Network and Its Implications for Human Disease. International Journal of Biological Sciences. 2013;9(10):1121-1133. https://doi.org/10.7150/ijbs.6666

BibTeX

@article{c283784ccbb543239118f9c3302deb5c,

title = "The Regulation of the Autophagic Network and Its Implications for Human Disease",

abstract = "Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.",

keywords = "Autophagy, ATGs, mTOR, UPR, FOXO1, HSF1, Heat Shock Proteins (HSP), Human diseases, FOXO TRANSCRIPTION FACTORS, UNFOLDED PROTEIN RESPONSE, HEAT-SHOCK PROTEINS, PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES, ENDOPLASMIC-RETICULUM STRESS, BECLIN 1-DEPENDENT AUTOPHAGY, MESSENGER-RNA TRANSLATION, ER STRESS, LIFE-SPAN, CAENORHABDITIS-ELEGANS",

author = "Jing Yang and Serena Carra and Wei-Guo Zhu and Kampinga, {Harm H.}",

year = "2013",

doi = "10.7150/ijbs.6666",

language = "English",

volume = "9",

pages = "1121--1133",

journal = "International Journal of Biological Sciences",

issn = "1449-2288",

number = "10",

}

RIS

TY - JOUR

T1 - The Regulation of the Autophagic Network and Its Implications for Human Disease

AU - Yang, Jing

AU - Carra, Serena

AU - Zhu, Wei-Guo

AU - Kampinga, Harm H.

PY - 2013

Y1 - 2013

N2 - Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.

AB - Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.

KW - Autophagy

KW - ATGs

KW - mTOR

KW - UPR

KW - FOXO1

KW - HSF1

KW - Heat Shock Proteins (HSP)

KW - Human diseases

KW - FOXO TRANSCRIPTION FACTORS

KW - UNFOLDED PROTEIN RESPONSE

KW - HEAT-SHOCK PROTEINS

KW - PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES

KW - ENDOPLASMIC-RETICULUM STRESS

KW - BECLIN 1-DEPENDENT AUTOPHAGY

KW - MESSENGER-RNA TRANSLATION

KW - ER STRESS

KW - LIFE-SPAN

KW - CAENORHABDITIS-ELEGANS

U2 - 10.7150/ijbs.6666

DO - 10.7150/ijbs.6666

M3 - Review article

C2 - 24339733

VL - 9

SP - 1121

EP - 1133

JO - International Journal of Biological Sciences

JF - International Journal of Biological Sciences

SN - 1449-2288

IS - 10

ER -

ID: 13654000

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