Publication

The Regulation of the Autophagic Network and Its Implications for Human Disease

Yang, J., Carra, S., Zhu, W-G. & Kampinga, H. H., 2013, In : International Journal of Biological Sciences. 9, 10, p. 1121-1133 13 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Autophagy has attracted a lot of attention in recent years. More and more proteins and signaling pathways have been discovered that somehow feed into the autophagy regulatory pathways. Regulation of autophagy is complex and condition-specific, and in several diseases, autophagic fluxes are changed. Here, we review the most well-established concepts in this field as well as the reported signaling pathways or components which steer the autophagy machinery. Furthermore, we will highlight how autophagic fluxes are changed in various diseases either as cause for or as response to deal with an altered cellular homeostasis and how modulation of autophagy might be used as potential therapy for such diseases.

Original languageEnglish
Pages (from-to)1121-1133
Number of pages13
JournalInternational Journal of Biological Sciences
Volume9
Issue number10
Publication statusPublished - 2013

    Keywords

  • Autophagy, ATGs, mTOR, UPR, FOXO1, HSF1, Heat Shock Proteins (HSP), Human diseases, FOXO TRANSCRIPTION FACTORS, UNFOLDED PROTEIN RESPONSE, HEAT-SHOCK PROTEINS, PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES, ENDOPLASMIC-RETICULUM STRESS, BECLIN 1-DEPENDENT AUTOPHAGY, MESSENGER-RNA TRANSLATION, ER STRESS, LIFE-SPAN, CAENORHABDITIS-ELEGANS

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