Publication

The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler

de Boer, A. H., Hagedoorn, P., Gjaltema, D., Lambregts, D., Irngartinger, M. & Frijlink, H. W., Dec-2004, In : Pharmaceutical Research. 21, 12, p. 2158-2166 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

de Boer, A. H., Hagedoorn, P., Gjaltema, D., Lambregts, D., Irngartinger, M., & Frijlink, H. W. (2004). The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler. Pharmaceutical Research, 21(12), 2158-2166. https://doi.org/10.1007/s11095-004-7668-4

Author

de Boer, Anne H ; Hagedoorn, Paul ; Gjaltema, Doetie ; Lambregts, Dorette ; Irngartinger, Meike ; Frijlink, Henderik W. / The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler. In: Pharmaceutical Research. 2004 ; Vol. 21, No. 12. pp. 2158-2166.

Harvard

de Boer, AH, Hagedoorn, P, Gjaltema, D, Lambregts, D, Irngartinger, M & Frijlink, HW 2004, 'The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler', Pharmaceutical Research, vol. 21, no. 12, pp. 2158-2166. https://doi.org/10.1007/s11095-004-7668-4

Standard

The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler. / de Boer, Anne H; Hagedoorn, Paul; Gjaltema, Doetie; Lambregts, Dorette; Irngartinger, Meike; Frijlink, Henderik W.

In: Pharmaceutical Research, Vol. 21, No. 12, 12.2004, p. 2158-2166.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

de Boer AH, Hagedoorn P, Gjaltema D, Lambregts D, Irngartinger M, Frijlink HW. The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler. Pharmaceutical Research. 2004 Dec;21(12):2158-2166. https://doi.org/10.1007/s11095-004-7668-4


BibTeX

@article{02073e119af44f0194d3b4a78ab3beee,
title = "The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler",
abstract = "Purpose. To investigate the rate with which drug particles are detached from carrier particles in adhesive mixtures when the action of the separation forces during inhalation is sustained by circulation of the powder dose in an air classifier. Methods. Residual drug on retained carrier particles from different adhesive mixture compositions has been analyzed after different circulation times in the classifier (0.5 to 6 s). For calculation of the detachment rate within the first 0.5 s of inhalation, the optical concentration of the aerosol from the classifier has been measured with laser diffraction technique. Results. Drug detachment from carrier crystals during inhalation increases not only with the flow rate but also with the time during which the action of the separation forces (at a constant flow rate) is sustained. The detachment rate at the same flow rate varies with the carrier size fraction and carrier payload and is clearly highest within the first 0.5 s of inhalation. Conclusions. Drug detachment from carrier approaches first-order reaction within the first half-second of inhalation. But at longer circulation times in the classifier, the ratio of removal to adhesive forces decreases dramatically. To increase the detached fraction of drug during inhalation at a constant flow rate, a short residence time for the powder in the de-agglomerator between 0.5 and 2 s is desired. {\circledC} 2004 Springer Science+Business Media, Inc.",
keywords = "Adhesive mixtures, Air classifier, Carrier residue, Dry powder inhaler with residence time, Particle detachment rate, budesonide, drug carrier, aerosol, article, circulation, concentration response, crystal structure, drug delivery system, drug formulation, drug release, exercise, flow rate, force, laser diffraction, powder inhaler, priority journal, sustained drug release",
author = "{de Boer}, {Anne H} and Paul Hagedoorn and Doetie Gjaltema and Dorette Lambregts and Meike Irngartinger and Frijlink, {Henderik W}",
year = "2004",
month = "12",
doi = "10.1007/s11095-004-7668-4",
language = "English",
volume = "21",
pages = "2158--2166",
journal = "Pharmaceutical Research",
issn = "0724-8741",
publisher = "SPRINGER/PLENUM PUBLISHERS",
number = "12",

}

RIS

TY - JOUR

T1 - The rate of drug particle detachment from carrier crystals in an air classifier-based inhaler

AU - de Boer, Anne H

AU - Hagedoorn, Paul

AU - Gjaltema, Doetie

AU - Lambregts, Dorette

AU - Irngartinger, Meike

AU - Frijlink, Henderik W

PY - 2004/12

Y1 - 2004/12

N2 - Purpose. To investigate the rate with which drug particles are detached from carrier particles in adhesive mixtures when the action of the separation forces during inhalation is sustained by circulation of the powder dose in an air classifier. Methods. Residual drug on retained carrier particles from different adhesive mixture compositions has been analyzed after different circulation times in the classifier (0.5 to 6 s). For calculation of the detachment rate within the first 0.5 s of inhalation, the optical concentration of the aerosol from the classifier has been measured with laser diffraction technique. Results. Drug detachment from carrier crystals during inhalation increases not only with the flow rate but also with the time during which the action of the separation forces (at a constant flow rate) is sustained. The detachment rate at the same flow rate varies with the carrier size fraction and carrier payload and is clearly highest within the first 0.5 s of inhalation. Conclusions. Drug detachment from carrier approaches first-order reaction within the first half-second of inhalation. But at longer circulation times in the classifier, the ratio of removal to adhesive forces decreases dramatically. To increase the detached fraction of drug during inhalation at a constant flow rate, a short residence time for the powder in the de-agglomerator between 0.5 and 2 s is desired. © 2004 Springer Science+Business Media, Inc.

AB - Purpose. To investigate the rate with which drug particles are detached from carrier particles in adhesive mixtures when the action of the separation forces during inhalation is sustained by circulation of the powder dose in an air classifier. Methods. Residual drug on retained carrier particles from different adhesive mixture compositions has been analyzed after different circulation times in the classifier (0.5 to 6 s). For calculation of the detachment rate within the first 0.5 s of inhalation, the optical concentration of the aerosol from the classifier has been measured with laser diffraction technique. Results. Drug detachment from carrier crystals during inhalation increases not only with the flow rate but also with the time during which the action of the separation forces (at a constant flow rate) is sustained. The detachment rate at the same flow rate varies with the carrier size fraction and carrier payload and is clearly highest within the first 0.5 s of inhalation. Conclusions. Drug detachment from carrier approaches first-order reaction within the first half-second of inhalation. But at longer circulation times in the classifier, the ratio of removal to adhesive forces decreases dramatically. To increase the detached fraction of drug during inhalation at a constant flow rate, a short residence time for the powder in the de-agglomerator between 0.5 and 2 s is desired. © 2004 Springer Science+Business Media, Inc.

KW - Adhesive mixtures

KW - Air classifier

KW - Carrier residue

KW - Dry powder inhaler with residence time

KW - Particle detachment rate

KW - budesonide

KW - drug carrier

KW - aerosol

KW - article

KW - circulation

KW - concentration response

KW - crystal structure

KW - drug delivery system

KW - drug formulation

KW - drug release

KW - exercise

KW - flow rate

KW - force

KW - laser diffraction

KW - powder inhaler

KW - priority journal

KW - sustained drug release

U2 - 10.1007/s11095-004-7668-4

DO - 10.1007/s11095-004-7668-4

M3 - Article

VL - 21

SP - 2158

EP - 2166

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 12

ER -

ID: 1251143