Publication

The puzzling origin of the autophagosomal membrane

Mari, M., Tooze, S. A. & Reggiori, F., 2011, In : F1000 Biology Reports. 3, p. 25

Research output: Contribution to journalReview articleAcademicpeer-review

Autophagy is one of the newest and fastest emerging research areas in biomedical life sciences. Autophagosomes, large double-membrane vesicles enclosing cytoplasmic components targeted for degradation, are the hallmark of this catabolic pathway. The origin of the lipid bilayers composing these transport carriers has been the central enigma of the field since the discovery of autophagy. A series of recent studies has implicated several cellular organelles as the possible source of the autophagosomal membranes, if anything further clouding our view. In this compendium, we will discuss these apparently contradictory results and briefly emphasize the relevance of determining the lipid source used for autophagy for future translational research, for example in drug discovery programs.

Original languageEnglish
Pages (from-to)25
JournalF1000 Biology Reports
Volume3
Publication statusPublished - 2011
Externally publishedYes

ID: 16003110