The prognostic value of tumor mitotic rate in children and adolescents with cutaneous melanoma: A retrospective cohort study

Ipenburg, N. A., Lo, S. N., Vilain, R. E., Holtkamp, L. H. J., Wilmott, J. S., Nieweg, O. E., Thompson, J. F. & Scolyer, R. A., Apr-2020, In : Journal of the American Academy of Dermatology. 82, 4, p. 910-919 10 p.

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  • The prognostic value of tumor mitotic rate in children and adolescents with cutaneous melanoma_ A retrospective cohort study _ Elsevier Enhanced Reader

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  • Norbertus A. Ipenburg
  • Serigne N. Lo
  • Ricardo E. Vilain
  • Lodewijka H. J. Holtkamp
  • James S. Wilmott
  • Omgo E. Nieweg
  • John F. Thompson
  • Richard A. Scolyer

Background: Mitotic rate is a strong predictor of outcome in adult patients with primary cutaneous melanoma, but for children and adolescent patients this is unknown.

Objective: We sought to assess the prognostic value of primary tumor mitotic rate in children and adolescents with primary melanoma.

Methods: This was a cohort study of 156 patients who were

Results: Thirteen of 156 patients (8%) were children. The mitotic rate was >= 1/mm(2) in 104 patients (67%) and correlated with increasing Breslow thickness. A positive sentinel node was found in 23 of 61 patients (38%) in whom a sentinel lymph node biopsy specimen was obtained. The median follow-up was 61 months. Five-year melanoma-specific and recurrence-free survival rates were 91% and 84%, respectively. Mitotic rate was a stronger predictor of outcome than tumor thickness and was the only factor independently associated with recurrence-free survival.

Limitations: This research was conducted at a single institution and the sample size was small.

Conclusion: Mitotic rate is an independent predictor of recurrence-free survival in children and adolescents with clinically localized melanoma.

Original languageEnglish
Pages (from-to)910-919
Number of pages10
JournalJournal of the American Academy of Dermatology
Issue number4
Publication statusPublished - Apr-2020


  • adolescent, children, dermatopathology, melanoma, mitosis, mitotic rate, oncology, pathology, pediatric, prognosis, recurrence, SINGLE-INSTITUTION EXPERIENCE, AMERICAN JOINT COMMITTEE, PEDIATRIC MELANOMA, MALIGNANT-MELANOMA, SURVIVAL, MULTICENTER, OUTCOMES, YOUNG, AGE

ID: 121210876