The prognostic value of serial EEG recordings following acute neonatal asphyxia in full-term infants

Zeinstra, E., Fock, J. M., Begeer, J. H., van Weerden, T. W., Maurits, N. M. & Zweens, M. J., 2001, In : European Journal of Paediatric Neurology. 5, 4, p. 155-160 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Perinatal asphyxia is one of the major causes of non-progressive neurological deficits seen in children. It is reported that currently no set of parameters allowing for accurate prediction of prognosis following severe perinatal asphyxia is available. Even electroencephalogram (EEG) recordings, which are known to give a fairly good prediction of long-term outcome, have their flaws. The aim of this prospective study was to evaluate the additional value of serial EEGs in full-term infants. In all, 36 infants were enrolled. All met strict entrance criteria, received standard treatment and underwent two EEGs according to a pre-set protocol: the first between 12 and 36 hours post-partum, the second between 7 and 9 days post-partum. It is clearly demonstrated that serial EEG recordings do enhance the prognostic value of the EEG. Moreover, distinct progression seen in serial EEGs is highly prognostic for a normal outcome and has even more prognostic value than one single severely abnormal EEG. A better indication of future outcome is obtained from serial EEGs.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalEuropean Journal of Paediatric Neurology
Issue number4
Publication statusPublished - 2001


  • Asphyxia Neonatorum, Brain Damage, Chronic, Cerebral Cortex, Electroencephalography, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Predictive Value of Tests, Prognosis, Prospective Studies, Journal Article

ID: 37678001