Publication

The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin

Balink, H., Veeger, N. J. G. M., Bennink, R. J., Slart, R. H. J. A., Holleman, F., van Eck-Smit, B. L. F. & Verberne, H. J., Jun-2015, In : Nuclear Medicine Communications. 36, 6, p. 604-609 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Balink, H., Veeger, N. J. G. M., Bennink, R. J., Slart, R. H. J. A., Holleman, F., van Eck-Smit, B. L. F., & Verberne, H. J. (2015). The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin. Nuclear Medicine Communications, 36(6), 604-609. https://doi.org/10.1097/MNM.0000000000000300

Author

Balink, Hans ; Veeger, Nic J. G. M. ; Bennink, Roel J. ; Slart, Riemer H. J. A. ; Holleman, Frits ; van Eck-Smit, Berthe L. F. ; Verberne, Hein J. / The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin. In: Nuclear Medicine Communications. 2015 ; Vol. 36, No. 6. pp. 604-609.

Harvard

Balink, H, Veeger, NJGM, Bennink, RJ, Slart, RHJA, Holleman, F, van Eck-Smit, BLF & Verberne, HJ 2015, 'The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin', Nuclear Medicine Communications, vol. 36, no. 6, pp. 604-609. https://doi.org/10.1097/MNM.0000000000000300

Standard

The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin. / Balink, Hans; Veeger, Nic J. G. M.; Bennink, Roel J.; Slart, Riemer H. J. A.; Holleman, Frits; van Eck-Smit, Berthe L. F.; Verberne, Hein J.

In: Nuclear Medicine Communications, Vol. 36, No. 6, 06.2015, p. 604-609.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Balink H, Veeger NJGM, Bennink RJ, Slart RHJA, Holleman F, van Eck-Smit BLF et al. The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin. Nuclear Medicine Communications. 2015 Jun;36(6):604-609. https://doi.org/10.1097/MNM.0000000000000300


BibTeX

@article{797594dc6a284ff8a148927d8e6d7ce3,
title = "The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin",
abstract = "OBJECTIVES: The objective of this study was to determine the predictive value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to a positive fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) result in patients with inflammation of unknown origin and fever of unknown origin.PATIENTS AND METHODS: Individual data of 498 patients were retrieved from three retrospective studies. Receiver operating characteristic derived areas under the curve were used to assess F-FDG PET/CT versus age, CRP, and ESR. The discriminative value of age, CRP, and ESR related to F-FDG PET/CT was examined using the net reclassification improvement (NRI).RESULTS: A diagnosis was established in 331 patients; F-FDG PET/CT had a diagnostic accuracy of 89{\%}. F-FDG PET/CT had the highest area under the curve (0.89, P<0.001). The addition of F-FDG PET/CT to a diagnosis prediction model including age, CRP, and ESR resulted in an NRI of 42{\%} (P<0.001). In the same model with CRP values below 20 mg/l or ESR values below 20 mm/h, the NRI was 64{\%} (P<0.001) and 29{\%} (P=0.059), respectively. In 30 of 91 patients with CRP less than 10 mg/l, a diagnosis could be established; F-FDG PET/CT was 100{\%} true negative only in patients with CRP levels less than 5 mg/l.CONCLUSION: In patients with fever of unknown origin or inflammation of unknown origin, compared with elevated ESR levels, elevated CRP levels more often indicate a true positive F-FDG PET/CT outcome.In addition, F-FDG PET/CT, compared with CRP and ESR, shows the highest discrimination of patients with possible disabling disease.",
keywords = "C-reactive protein, erythrocyte sedimentation rate, F-18-FDG PET, CT, fever of unknown origin, inflammation of unknown origin, LARGE VESSEL VASCULITIS, MULTICENTER, MANAGEMENT, UTILITY",
author = "Hans Balink and Veeger, {Nic J. G. M.} and Bennink, {Roel J.} and Slart, {Riemer H. J. A.} and Frits Holleman and {van Eck-Smit}, {Berthe L. F.} and Verberne, {Hein J.}",
year = "2015",
month = "6",
doi = "10.1097/MNM.0000000000000300",
language = "English",
volume = "36",
pages = "604--609",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "6",

}

RIS

TY - JOUR

T1 - The predictive value of C-reactive protein and erythrocyte sedimentation rate for 18F-FDG PET/CT outcome in patients with fever and inflammation of unknown origin

AU - Balink, Hans

AU - Veeger, Nic J. G. M.

AU - Bennink, Roel J.

AU - Slart, Riemer H. J. A.

AU - Holleman, Frits

AU - van Eck-Smit, Berthe L. F.

AU - Verberne, Hein J.

PY - 2015/6

Y1 - 2015/6

N2 - OBJECTIVES: The objective of this study was to determine the predictive value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to a positive fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) result in patients with inflammation of unknown origin and fever of unknown origin.PATIENTS AND METHODS: Individual data of 498 patients were retrieved from three retrospective studies. Receiver operating characteristic derived areas under the curve were used to assess F-FDG PET/CT versus age, CRP, and ESR. The discriminative value of age, CRP, and ESR related to F-FDG PET/CT was examined using the net reclassification improvement (NRI).RESULTS: A diagnosis was established in 331 patients; F-FDG PET/CT had a diagnostic accuracy of 89%. F-FDG PET/CT had the highest area under the curve (0.89, P<0.001). The addition of F-FDG PET/CT to a diagnosis prediction model including age, CRP, and ESR resulted in an NRI of 42% (P<0.001). In the same model with CRP values below 20 mg/l or ESR values below 20 mm/h, the NRI was 64% (P<0.001) and 29% (P=0.059), respectively. In 30 of 91 patients with CRP less than 10 mg/l, a diagnosis could be established; F-FDG PET/CT was 100% true negative only in patients with CRP levels less than 5 mg/l.CONCLUSION: In patients with fever of unknown origin or inflammation of unknown origin, compared with elevated ESR levels, elevated CRP levels more often indicate a true positive F-FDG PET/CT outcome.In addition, F-FDG PET/CT, compared with CRP and ESR, shows the highest discrimination of patients with possible disabling disease.

AB - OBJECTIVES: The objective of this study was to determine the predictive value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to a positive fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) result in patients with inflammation of unknown origin and fever of unknown origin.PATIENTS AND METHODS: Individual data of 498 patients were retrieved from three retrospective studies. Receiver operating characteristic derived areas under the curve were used to assess F-FDG PET/CT versus age, CRP, and ESR. The discriminative value of age, CRP, and ESR related to F-FDG PET/CT was examined using the net reclassification improvement (NRI).RESULTS: A diagnosis was established in 331 patients; F-FDG PET/CT had a diagnostic accuracy of 89%. F-FDG PET/CT had the highest area under the curve (0.89, P<0.001). The addition of F-FDG PET/CT to a diagnosis prediction model including age, CRP, and ESR resulted in an NRI of 42% (P<0.001). In the same model with CRP values below 20 mg/l or ESR values below 20 mm/h, the NRI was 64% (P<0.001) and 29% (P=0.059), respectively. In 30 of 91 patients with CRP less than 10 mg/l, a diagnosis could be established; F-FDG PET/CT was 100% true negative only in patients with CRP levels less than 5 mg/l.CONCLUSION: In patients with fever of unknown origin or inflammation of unknown origin, compared with elevated ESR levels, elevated CRP levels more often indicate a true positive F-FDG PET/CT outcome.In addition, F-FDG PET/CT, compared with CRP and ESR, shows the highest discrimination of patients with possible disabling disease.

KW - C-reactive protein

KW - erythrocyte sedimentation rate

KW - F-18-FDG PET

KW - CT

KW - fever of unknown origin

KW - inflammation of unknown origin

KW - LARGE VESSEL VASCULITIS

KW - MULTICENTER

KW - MANAGEMENT

KW - UTILITY

U2 - 10.1097/MNM.0000000000000300

DO - 10.1097/MNM.0000000000000300

M3 - Article

VL - 36

SP - 604

EP - 609

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 6

ER -

ID: 17017775