Publication

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Taylor, D. M., Aronow, B. J., Tan, K., Bernt, K., Salomonis, N., Greene, C. S., Frolova, A., Henrickson, S. E., Wells, A., Pei, L., Jaiswal, J. K., Whitsett, J., Hamilton, K. E., MacParland, S. A., Kelsen, J., Heuckeroth, R. O., Potter, S. S., Vella, L. A., Terry, N. A., Ghanem, L. R., Kennedy, B. C., Helbig, I., Sullivan, K. E., Castelo-Soccio, L., Kreigstein, A., Herse, F., Nawijn, M. C., Koppelman, G. H., Haendel, M., Harris, N. L., Rokita, J. L., Zhang, Y., Regev, A., Rozenblatt-Rosen, O., Rood, J. E., Tickle, T. L., Vento-Tormo, R., Alimohamed, S., Lek, M., Mar, J. C., Loomes, K. M., Barrett, D. M., Uapinyoying, P., Beggs, A. H., Agrawal, P. B., Chen, Y-W., Muir, A. B., Garmire, L. X., Snapper, S. B., Nazarian, J., Seeholzer, S. H., Fazelinia, H., Singh, L. N., Faryabi, R. B., Raman, P., Dawany, N., Xie, H. M., Devkota, B., Diskin, S. J., Anderson, S. A., Rappaport, E. F., Peranteau, W., Wikenheiser-Brokamp, K. A., Teichmann, S., Wallace, D., Peng, T., Ding, Y., Kim, M. S., Xing, Y., Kong, S. W., Bonnemann, C. G., Mandl, K. D. & White, P. S., 8-Apr-2019, In : Developmental Cell. 49, 1, p. 10-29 20 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Deanne M. Taylor
  • Bruce J. Aronow
  • Kai Tan
  • Kathrin Bernt
  • Nathan Salomonis
  • Casey S. Greene
  • Alina Frolova
  • Sarah E. Henrickson
  • Andrew Wells
  • Liming Pei
  • Jyoti K. Jaiswal
  • Jeffrey Whitsett
  • Kathryn E. Hamilton
  • Sonya A. MacParland
  • Judith Kelsen
  • Robert O. Heuckeroth
  • S. Steven Potter
  • Laura A. Vella
  • Natalie A. Terry
  • Louis R. Ghanem
  • Benjamin C. Kennedy
  • Ingo Helbig
  • Kathleen E. Sullivan
  • Leslie Castelo-Soccio
  • Arnold Kreigstein
  • Florian Herse
  • Martijn C. Nawijn
  • Gerard H. Koppelman
  • Melissa Haendel
  • Nomi L. Harris
  • Jo Lynne Rokita
  • Yuanchao Zhang
  • Aviv Regev
  • Orit Rozenblatt-Rosen
  • Jennifer E. Rood
  • Timothy L. Tickle
  • Roser Vento-Tormo
  • Saif Alimohamed
  • Monkol Lek
  • Jessica C. Mar
  • Kathleen M. Loomes
  • David M. Barrett
  • Prech Uapinyoying
  • Alan H. Beggs
  • Pankaj B. Agrawal
  • Yi-Wen Chen
  • Amanda B. Muir
  • Lana X. Garmire
  • Scott B. Snapper
  • Javad Nazarian
  • Steven H. Seeholzer
  • Hossein Fazelinia
  • Larry N. Singh
  • Robert B. Faryabi
  • Pichai Raman
  • Noor Dawany
  • Hongbo Michael Xie
  • Batsal Devkota
  • Sharon J. Diskin
  • Stewart A. Anderson
  • Eric F. Rappaport
  • William Peranteau
  • Kathryn A. Wikenheiser-Brokamp
  • Sarah Teichmann
  • Douglas Wallace
  • Tao Peng
  • Yang-yang Ding
  • Man S. Kim
  • Yi Xing
  • Sek Won Kong
  • Carsten G. Bonnemann
  • Kenneth D. Mandl
  • Peter S. White

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

Original languageEnglish
Pages (from-to)10-29
Number of pages20
JournalDevelopmental Cell
Volume49
Issue number1
Publication statusPublished - 8-Apr-2019

    Keywords

  • INFLAMMATORY-BOWEL-DISEASE, ACUTE LYMPHOBLASTIC-LEUKEMIA, CHRONIC KIDNEY-DISEASE, BILIARY ATRESIA, SATELLITE CELLS, GENE-EXPRESSION, HEART-DISEASE, RNA-SEQ, SOMATIC MUTATIONS, CHILDRENS HEALTH

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