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The many facets of homologous recombination at telomeres

Claussin, C. & Chang, M., 1-Sep-2015, In : Microbial Cell. 2, 9, p. 308-321 14 p.

Research output: Contribution to journalArticleAcademicpeer-review

The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctional telomere may resemble a DNA double-strand break (DSB), which is a severe form of DNA damage. The presence of one DSB is sufficient to drive cell cycle arrest and cell death. Therefore cells have evolved mechanisms to repair DSBs such as homologous recombination (HR). HR-mediated repair of telomeres can lead to genome instability, a hallmark of cancer cells, which is why such repair is normally inhibited. However, some HR-mediated processes are required for proper telomere function. The need for some recombination activities at telomeres but not others necessitates careful and complex regulation, defects in which can lead to catastrophic consequences. Furthermore, some cell types can maintain telomeres via telomerase-independent, recombination-mediated mechanisms. In humans, these mechanisms are called Alternative Lengthening of Telomeres (ALT) and are used in a subset of human cancer cells. In this review, we summarize the different recombination activities occurring at telomeres and discuss how they are regulated. Much of the current knowledge is derived from work using yeast models, which is the focus of this review, but relevant studies in mammals are also included.
Original languageEnglish
Pages (from-to)308-321
Number of pages14
JournalMicrobial Cell
Volume2
Issue number9
Publication statusPublished - 1-Sep-2015

    Keywords

  • homologous recombination, telomeres, alternative lengthening of telomeres, telomerase-independent telomere maintenance, break-induced replication

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