The long road: the autophagic network and TP53/ASXL1 aberrations in hematopoietic malignancies

Hilgendorf, S., 2018, [Groningen]: Rijksuniversiteit Groningen. 189 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Title and contents

    Final publisher's version, 176 KB, PDF-document

  • Chapter 1

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  • Chapter 2

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  • Chapter 3

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  • Chapter 4

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  • Chapter 5

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  • Chapter 6

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  • Complete thesis

    Final publisher's version, 17 MB, PDF-document

  • Propositions

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Development of cancer may have several causes. In this thesis, we focused on specific genetic and metabolite factors that may play a role in the development of blood cancer (leukemia). In the first part of this thesis, the function of a gene was impaired in stem cells to determine if that allows for enhanced, even cancerous growth of cells in the petri dish or even in a mouse model. Altering this and another’s gene activity did not lead to uncontrolled growth but presented with abnormal cell differentiation and development.
In the second of this thesis, we focused on self-eating of cells (autophagy), which can be used by cancer cells to become resistant to chemo- or radiotherapeutic treatment. We found that a certain genetic abnormality in leukemic stem cells may lead to enhanced survival of these cells during blockage of autophagy. In the end, we describe in an extensive review how autophagy is involved in cancer development and maintenance. We further discussed how the multi-faceted role of autophagy in cancer could be exploited for cancer therapy.
Translated title of the contributionEen lange weg: Het autofagienetwerk en TP53/ASXL1 mutaties in hematopoietische afwijkingen
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date2-Jul-2018
Place of Publication[Groningen]
Print ISBNs978-94-6375-024-0
Publication statusPublished - 2018

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