Publication

The lateral hypothalamus: A site for integration of nutrient and fluid balance

van Dijk, G., Evers, S. S., Guidotti, S., Thornton, S. N., Scheurink, A. J. W. & Nyakas, C., 10-Aug-2011, In : Behavioral Brain Research. 221, 2, p. 481-487 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

van Dijk, G., Evers, S. S., Guidotti, S., Thornton, S. N., Scheurink, A. J. W., & Nyakas, C. (2011). The lateral hypothalamus: A site for integration of nutrient and fluid balance. Behavioral Brain Research, 221(2), 481-487. https://doi.org/10.1016/j.bbr.2011.01.047

Author

van Dijk, Gertjan ; Evers, Simon S. ; Guidotti, Stefano ; Thornton, Simon N. ; Scheurink, Anton J. W. ; Nyakas, Csaba. / The lateral hypothalamus : A site for integration of nutrient and fluid balance. In: Behavioral Brain Research. 2011 ; Vol. 221, No. 2. pp. 481-487.

Harvard

van Dijk, G, Evers, SS, Guidotti, S, Thornton, SN, Scheurink, AJW & Nyakas, C 2011, 'The lateral hypothalamus: A site for integration of nutrient and fluid balance', Behavioral Brain Research, vol. 221, no. 2, pp. 481-487. https://doi.org/10.1016/j.bbr.2011.01.047

Standard

The lateral hypothalamus : A site for integration of nutrient and fluid balance. / van Dijk, Gertjan; Evers, Simon S.; Guidotti, Stefano; Thornton, Simon N.; Scheurink, Anton J. W.; Nyakas, Csaba.

In: Behavioral Brain Research, Vol. 221, No. 2, 10.08.2011, p. 481-487.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

van Dijk G, Evers SS, Guidotti S, Thornton SN, Scheurink AJW, Nyakas C. The lateral hypothalamus: A site for integration of nutrient and fluid balance. Behavioral Brain Research. 2011 Aug 10;221(2):481-487. https://doi.org/10.1016/j.bbr.2011.01.047


BibTeX

@article{de66b98d448b474b9ef2b3816c6f1d31,
title = "The lateral hypothalamus: A site for integration of nutrient and fluid balance",
abstract = "This paper reviews seemingly obligatory relations between nutrient and fluid balance. A relatively novel neuronal pathway involving interplay between acetylcholine and the melanocortins, alpha MSH and AGRP in the arcuate nucleus (Arc) of the hypothalamus projecting to the lateral hypothalamus (LH) may bridge this gap. In the fasted condition, increased expression of MCH (due to muscarinic-3 receptor stimulation and low melanocortin tone) and neuronal release of MCH (via Orexin signaling) underlies a drive towards positive energy balance, increased B cell capacity to secrete insulin, and this is associated with optimal fluid homeostasis. A hypohydrated state is hypothesized to yield downregulation of leptin signaling (potentially via inhibitory effects of osmotic stress on mTOR), but osmotic stress may prevent MCH expression via the OVLT-SFO complex. If this occurs in an obese state, impaired pancreatic B cell capacity and peripheral insulin insensitivity as a result of hypohydration may underlie cardio-metabolic diseases. (C) 2011 Elsevier B.V. All rights reserved.",
keywords = "Body water, Drinking, Feeding, Osmotic stress, Obesity, Insulin, MELANIN-CONCENTRATING HORMONE, IBOTENIC ACID LESIONS, METHYL-D-ASPARTATE, FOOD-INTAKE, BODY-WEIGHT, CHOLINERGIC STIMULATION, SUBFORNICAL ORGAN, ARCUATE NUCLEUS, ACETYLCHOLINE-RELEASE, DEHYDRATION ANOREXIA",
author = "{van Dijk}, Gertjan and Evers, {Simon S.} and Stefano Guidotti and Thornton, {Simon N.} and Scheurink, {Anton J. W.} and Csaba Nyakas",
year = "2011",
month = aug,
day = "10",
doi = "10.1016/j.bbr.2011.01.047",
language = "English",
volume = "221",
pages = "481--487",
journal = "Behavioral Brain Research",
issn = "0166-4328",
publisher = "ELSEVIER SCIENCE BV",
number = "2",

}

RIS

TY - JOUR

T1 - The lateral hypothalamus

T2 - A site for integration of nutrient and fluid balance

AU - van Dijk, Gertjan

AU - Evers, Simon S.

AU - Guidotti, Stefano

AU - Thornton, Simon N.

AU - Scheurink, Anton J. W.

AU - Nyakas, Csaba

PY - 2011/8/10

Y1 - 2011/8/10

N2 - This paper reviews seemingly obligatory relations between nutrient and fluid balance. A relatively novel neuronal pathway involving interplay between acetylcholine and the melanocortins, alpha MSH and AGRP in the arcuate nucleus (Arc) of the hypothalamus projecting to the lateral hypothalamus (LH) may bridge this gap. In the fasted condition, increased expression of MCH (due to muscarinic-3 receptor stimulation and low melanocortin tone) and neuronal release of MCH (via Orexin signaling) underlies a drive towards positive energy balance, increased B cell capacity to secrete insulin, and this is associated with optimal fluid homeostasis. A hypohydrated state is hypothesized to yield downregulation of leptin signaling (potentially via inhibitory effects of osmotic stress on mTOR), but osmotic stress may prevent MCH expression via the OVLT-SFO complex. If this occurs in an obese state, impaired pancreatic B cell capacity and peripheral insulin insensitivity as a result of hypohydration may underlie cardio-metabolic diseases. (C) 2011 Elsevier B.V. All rights reserved.

AB - This paper reviews seemingly obligatory relations between nutrient and fluid balance. A relatively novel neuronal pathway involving interplay between acetylcholine and the melanocortins, alpha MSH and AGRP in the arcuate nucleus (Arc) of the hypothalamus projecting to the lateral hypothalamus (LH) may bridge this gap. In the fasted condition, increased expression of MCH (due to muscarinic-3 receptor stimulation and low melanocortin tone) and neuronal release of MCH (via Orexin signaling) underlies a drive towards positive energy balance, increased B cell capacity to secrete insulin, and this is associated with optimal fluid homeostasis. A hypohydrated state is hypothesized to yield downregulation of leptin signaling (potentially via inhibitory effects of osmotic stress on mTOR), but osmotic stress may prevent MCH expression via the OVLT-SFO complex. If this occurs in an obese state, impaired pancreatic B cell capacity and peripheral insulin insensitivity as a result of hypohydration may underlie cardio-metabolic diseases. (C) 2011 Elsevier B.V. All rights reserved.

KW - Body water

KW - Drinking

KW - Feeding

KW - Osmotic stress

KW - Obesity

KW - Insulin

KW - MELANIN-CONCENTRATING HORMONE

KW - IBOTENIC ACID LESIONS

KW - METHYL-D-ASPARTATE

KW - FOOD-INTAKE

KW - BODY-WEIGHT

KW - CHOLINERGIC STIMULATION

KW - SUBFORNICAL ORGAN

KW - ARCUATE NUCLEUS

KW - ACETYLCHOLINE-RELEASE

KW - DEHYDRATION ANOREXIA

U2 - 10.1016/j.bbr.2011.01.047

DO - 10.1016/j.bbr.2011.01.047

M3 - Review article

VL - 221

SP - 481

EP - 487

JO - Behavioral Brain Research

JF - Behavioral Brain Research

SN - 0166-4328

IS - 2

ER -

ID: 5340844