The lateral hypothalamus: A site for integration of nutrient and fluid balancevan Dijk, G., Evers, S. S., Guidotti, S., Thornton, S. N., Scheurink, A. J. W. & Nyakas, C., 10-Aug-2011, In : Behavioral Brain Research. 221, 2, p. 481-487 7 p.
Research output: Contribution to journal › Review article › Academic › peer-review
This paper reviews seemingly obligatory relations between nutrient and fluid balance. A relatively novel neuronal pathway involving interplay between acetylcholine and the melanocortins, alpha MSH and AGRP in the arcuate nucleus (Arc) of the hypothalamus projecting to the lateral hypothalamus (LH) may bridge this gap. In the fasted condition, increased expression of MCH (due to muscarinic-3 receptor stimulation and low melanocortin tone) and neuronal release of MCH (via Orexin signaling) underlies a drive towards positive energy balance, increased B cell capacity to secrete insulin, and this is associated with optimal fluid homeostasis. A hypohydrated state is hypothesized to yield downregulation of leptin signaling (potentially via inhibitory effects of osmotic stress on mTOR), but osmotic stress may prevent MCH expression via the OVLT-SFO complex. If this occurs in an obese state, impaired pancreatic B cell capacity and peripheral insulin insensitivity as a result of hypohydration may underlie cardio-metabolic diseases. (C) 2011 Elsevier B.V. All rights reserved.
|Number of pages||7|
|Journal||Behavioral Brain Research|
|Publication status||Published - 10-Aug-2011|
- Body water, Drinking, Feeding, Osmotic stress, Obesity, Insulin, MELANIN-CONCENTRATING HORMONE, IBOTENIC ACID LESIONS, METHYL-D-ASPARTATE, FOOD-INTAKE, BODY-WEIGHT, CHOLINERGIC STIMULATION, SUBFORNICAL ORGAN, ARCUATE NUCLEUS, ACETYLCHOLINE-RELEASE, DEHYDRATION ANOREXIA