Publication

The intestinal barrier in Parkinson’s disease: current state of knowledge

Ijzendoorn, van, S. C. D. & Derkinderen, P., Aug-2019, (Accepted/In press) In : Journal of Parkinson's Disease.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Author's version: The intestinal barrier in Parkinson’s disease: current state of knowledge

    Final author's version, 734 KB, PDF document

    Embargo ends: 01/08/2020

    Request copy

The intestinal barrier, which primarily consists of epithelial cells stitched together with
connecting proteins called tight junctions, plays a critical role in health and disease. It
is in close contact with the gut microbiota on its luminal side and with the enteric
neurons on the tissue side. Both microbiota and the enteric nervous system are
regulatory housekeepers of the intestinal barrier. Therefore, the recently observed
enteric neuropathology along with gut dysbiosis in Parkinson’s disease have prompted
research on intestinal permeability in this neurodegenerative disorder. In this minireview
we attempt to concisely summarize the current knowledge on intestinal barrier
in Parkinson’s disease. We envision future direction research that should be pursued
in order to demonstrate its possible role in disease development and progression.
Original languageEnglish
JournalJournal of Parkinson's Disease
Publication statusAccepted/In press - Aug-2019

View graph of relations

ID: 95168030