Publication

The influence of pregnancy and gender on perivascular innervation of rat posterior cerebral arteries

Aukes, A. M., Bishop, N., Godfrey, J. & Cipolla, M. J., Apr-2008, In : Reproductive Sciences. 15, 4, p. 411-419 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Annet M. Aukes
  • Nicole Bishop
  • Julie Godfrey
  • Marilyn J. Cipolla

The authors investigated the influence of pregnancy and gender on the density of trigeminal and sympathetic perivascular nerves in posterior cerebral arteries (PCA) and the reactivity to norepinephrine and calcitonin gene-related peptide (CGRP). PCAs were isolated from nonpregnant, late-pregnant, postpartum, and male rats, mounted and pressurized on an arteriograph chamber to obtain concentration-response curves to norepinephrine and CGRP. Arteries were immunostained for CGRP-, tyrosine hydroxylase, and protein gene product 9.5 (PGP 9.5)-containing perivascular nerves, and nerve density was determined morphologically. Pregnancy had a trophic effect on trigeminal perivascular innervation (P

Original languageEnglish
Pages (from-to)411-419
Number of pages9
JournalReproductive Sciences
Volume15
Issue number4
Publication statusPublished - Apr-2008

    Keywords

  • perivascular innervation, pial arteries, pregnancy, rat, GENE-RELATED PEPTIDE, SEX STEROID-HORMONES, DORSAL-ROOT GANGLIA, SYMPATHETIC-NERVES, BLOOD-VESSELS, HYPERTENSION, MIGRAINE, ECLAMPSIA, PATHOPHYSIOLOGY, CIRCULATION

ID: 4730017