Publication

The impact of frailty on depressive disorder in later life: Findings from the Netherlands Study of depression in older persons

Collard, R. M., Arts, M. H. L., Schene, A. H., Naarding, P., Voshaar, R. C. O. & Comijs, H. C., Jun-2017, In : European Psychiatry. 43, p. 66-72 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: Physical frailty and depressive symptoms are reciprocally related in community-based studies, but its prognostic impact on depressive disorder remains unknown.

Methods: A cohort of 378 older persons (>= 60 years) suffering from a depressive disorder (DSM-IV criteria) was reassessed at two-year follow-up. Depressive symptom severity was assessed every six months with the Inventory of Depressive Symptomatology, including a mood, motivational, and somatic subscale. Frailty was assessed according to the physical frailty phenotype at the baseline examination.

Results: For each additional frailty component, the odds of non-remission was 1.24 [95% CI = 1.01-1.52] (P = 040). Linear mixed models showed that only improvement of the motivational (P <001) subscale and the somatic subscale (P = 003) of the IDS over time were dependent on the frailty severity.

Conclusions: Physical frailty negatively impacts the course of late-life depression. Since only improvement of mood symptoms was independent of frailty severity, one may hypothesize that frailty and residual depression are easily mixed-up in psychiatric treatment.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalEuropean Psychiatry
Volume43
Publication statusPublished - Jun-2017

    Keywords

  • Frailty, Depression, Older persons, Netherlands study of depression in older persons, WOMEN AGED 65, PHYSICAL FRAILTY, GERIATRIC DEPRESSION, COMMUNITY, SARCOPENIA, ADULTS, CONSEQUENCES, DETERMINANTS, INFLAMMATION, PREVALENCE

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