Publication

The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

Schiller, H. B., Montoro, D. T., Simon, L. M., Rawlins, E. L., Meyer, K. B., Strunz, M., Vieira Braga, F., Timens, W., Koppelman, G. H., Budinger, G. R. S., Burgess, J. K., van den Berge, M., Theis, F. J., Regev, A., Kaminski, N., Rajagopal, J., Teichmann, S. A., Misharin, A. V. & Nawijn, M. C., Jul-2019, In : American Journal of Respiratory Cell and Molecular Biology. 61, 1, p. 31-41 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Schiller, H. B., Montoro, D. T., Simon, L. M., Rawlins, E. L., Meyer, K. B., Strunz, M., Vieira Braga, F., Timens, W., Koppelman, G. H., Budinger, G. R. S., Burgess, J. K., van den Berge, M., Theis, F. J., Regev, A., Kaminski, N., Rajagopal, J., Teichmann, S. A., Misharin, A. V., & Nawijn, M. C. (2019). The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. American Journal of Respiratory Cell and Molecular Biology, 61(1), 31-41. https://doi.org/10.1165/rcmb.2018-0416TR

Author

Schiller, Herbert B ; Montoro, Daniel T ; Simon, Lukas M ; Rawlins, Emma L ; Meyer, Kerstin B ; Strunz, Maximilian ; Vieira Braga, Felipe ; Timens, Wim ; Koppelman, Gerard H ; Budinger, G R Scott ; Burgess, Janette K ; van den Berge, Maarten ; Theis, Fabian J ; Regev, Aviv ; Kaminski, Naftali ; Rajagopal, Jayaraj ; Teichmann, Sarah A ; Misharin, Alexander V ; Nawijn, Martijn C. / The Human Lung Cell Atlas : A High-Resolution Reference Map of the Human Lung in Health and Disease. In: American Journal of Respiratory Cell and Molecular Biology. 2019 ; Vol. 61, No. 1. pp. 31-41.

Harvard

Schiller, HB, Montoro, DT, Simon, LM, Rawlins, EL, Meyer, KB, Strunz, M, Vieira Braga, F, Timens, W, Koppelman, GH, Budinger, GRS, Burgess, JK, van den Berge, M, Theis, FJ, Regev, A, Kaminski, N, Rajagopal, J, Teichmann, SA, Misharin, AV & Nawijn, MC 2019, 'The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease', American Journal of Respiratory Cell and Molecular Biology, vol. 61, no. 1, pp. 31-41. https://doi.org/10.1165/rcmb.2018-0416TR

Standard

The Human Lung Cell Atlas : A High-Resolution Reference Map of the Human Lung in Health and Disease. / Schiller, Herbert B; Montoro, Daniel T; Simon, Lukas M; Rawlins, Emma L; Meyer, Kerstin B; Strunz, Maximilian; Vieira Braga, Felipe; Timens, Wim; Koppelman, Gerard H; Budinger, G R Scott; Burgess, Janette K; van den Berge, Maarten; Theis, Fabian J; Regev, Aviv; Kaminski, Naftali; Rajagopal, Jayaraj; Teichmann, Sarah A; Misharin, Alexander V; Nawijn, Martijn C.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 61, No. 1, 07.2019, p. 31-41.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Schiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M et al. The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease. American Journal of Respiratory Cell and Molecular Biology. 2019 Jul;61(1):31-41. https://doi.org/10.1165/rcmb.2018-0416TR


BibTeX

@article{2fd29fa1240f4143bcf720dcc9b74d35,
title = "The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease",
abstract = "Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments, including the tissue resident structural and immune cells, the tissue matrix, and the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.",
keywords = "Human Cell Atlas, single-cell RNA sequencing, spatial transcriptomics, systems biology, LYMPHOID-TISSUE BALT, NUCLEUS RNA-SEQ, GENE-EXPRESSION, SINGLE, TRANSCRIPTOME, REGENERATION, PLASTICITY, HALLMARKS, CHILDREN",
author = "Schiller, {Herbert B} and Montoro, {Daniel T} and Simon, {Lukas M} and Rawlins, {Emma L} and Meyer, {Kerstin B} and Maximilian Strunz and {Vieira Braga}, Felipe and Wim Timens and Koppelman, {Gerard H} and Budinger, {G R Scott} and Burgess, {Janette K} and {van den Berge}, Maarten and Theis, {Fabian J} and Aviv Regev and Naftali Kaminski and Jayaraj Rajagopal and Teichmann, {Sarah A} and Misharin, {Alexander V} and Nawijn, {Martijn C}",
year = "2019",
month = jul,
doi = "10.1165/rcmb.2018-0416TR",
language = "English",
volume = "61",
pages = "31--41",
journal = "American Journal of Respiratory Cell and Molecular Biology",
issn = "1044-1549",
publisher = "AMER THORACIC SOC",
number = "1",

}

RIS

TY - JOUR

T1 - The Human Lung Cell Atlas

T2 - A High-Resolution Reference Map of the Human Lung in Health and Disease

AU - Schiller, Herbert B

AU - Montoro, Daniel T

AU - Simon, Lukas M

AU - Rawlins, Emma L

AU - Meyer, Kerstin B

AU - Strunz, Maximilian

AU - Vieira Braga, Felipe

AU - Timens, Wim

AU - Koppelman, Gerard H

AU - Budinger, G R Scott

AU - Burgess, Janette K

AU - van den Berge, Maarten

AU - Theis, Fabian J

AU - Regev, Aviv

AU - Kaminski, Naftali

AU - Rajagopal, Jayaraj

AU - Teichmann, Sarah A

AU - Misharin, Alexander V

AU - Nawijn, Martijn C

PY - 2019/7

Y1 - 2019/7

N2 - Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments, including the tissue resident structural and immune cells, the tissue matrix, and the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.

AB - Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments, including the tissue resident structural and immune cells, the tissue matrix, and the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.

KW - Human Cell Atlas

KW - single-cell RNA sequencing

KW - spatial transcriptomics

KW - systems biology

KW - LYMPHOID-TISSUE BALT

KW - NUCLEUS RNA-SEQ

KW - GENE-EXPRESSION

KW - SINGLE

KW - TRANSCRIPTOME

KW - REGENERATION

KW - PLASTICITY

KW - HALLMARKS

KW - CHILDREN

U2 - 10.1165/rcmb.2018-0416TR

DO - 10.1165/rcmb.2018-0416TR

M3 - Review article

C2 - 30995076

VL - 61

SP - 31

EP - 41

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

SN - 1044-1549

IS - 1

ER -

ID: 80040135