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The Hansenula polymorpha PDD7 gene is essential for macropexophagy and microautophagy

Komduur, JA., Veenhuis, M. & Kiel, JAKW., Mar-2003, In : Fems Yeast Research. 3, 1, p. 27-34 8 p., PII S1567-1356(02)00135-6.

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DOI

Hansenula polymorpha PDD genes are involved in the selective degradation of peroxisomes via macropexophagy. We have isolated various novel pdd mutants by a gene-tagging method. Here we describe the isolation and characterisation of PDD7, which encodes a protein with high sequence similarity (40% identity) to Saccharomyces cerevisiae Apg1p/Aut3p, previously described to be involved in random autophagy and the cytoplasm-to-vacuole targeting pathway. Our data indicate that HpPdd7p is essential for two processes that degrade peroxisomes, namely the highly selective process of macropexophagy and microautophagy, which occurs in H. polymorpha upon nitrogen starvation. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

Original languageEnglish
Article numberPII S1567-1356(02)00135-6
Pages (from-to)27-34
Number of pages8
JournalFems Yeast Research
Volume3
Issue number1
Publication statusPublished - Mar-2003

    Keywords

  • autophagy, methylotrophic yeast, peroxisome, pexophagy, selective peroxisome degradation, SACCHAROMYCES-CEREVISIAE, PEROXISOME DEGRADATION, SELECTIVE DEGRADATION, PICHIA-PASTORIS, YEAST, AUTOPHAGY, PROTEIN, CYTOPLASM, MEMBRANE, VACUOLE

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