Publication

The gut microbiome and metabolome of two riparian communities in the Amazon

Pires, E. S., Pires Hardoim, C. C., Miranda, K. R., Secco, D. A., Lobo, L. A., de Carvalho, D. P., Han, J., Borchers, C. H., Ferreira, R. B. R., Salles, J. F., Cavalcanti Pilotto Domingues, R. M. & Martha Antunes, L. C., 4-Sep-2019, In : Frontiers in Microbiology. 10, 13 p., 2003.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Pires, E. S., Pires Hardoim, C. C., Miranda, K. R., Secco, D. A., Lobo, L. A., de Carvalho, D. P., ... Martha Antunes, L. C. (2019). The gut microbiome and metabolome of two riparian communities in the Amazon. Frontiers in Microbiology, 10, [2003]. https://doi.org/10.3389/fmicb.2019.02003

Author

Pires, Eder Soares ; Pires Hardoim, Cristiane Cassiolato ; Miranda, Karla Rodrigues ; Secco, Danielle Angst ; Lobo, Leandro Araujo ; de Carvalho, Denise Pires ; Han, Jun ; Borchers, Christoph H. ; Ferreira, Rosana B. R. ; Salles, Joana Falcao ; Cavalcanti Pilotto Domingues, Regina Maria ; Martha Antunes, Luis Caetano. / The gut microbiome and metabolome of two riparian communities in the Amazon. In: Frontiers in Microbiology. 2019 ; Vol. 10.

Harvard

Pires, ES, Pires Hardoim, CC, Miranda, KR, Secco, DA, Lobo, LA, de Carvalho, DP, Han, J, Borchers, CH, Ferreira, RBR, Salles, JF, Cavalcanti Pilotto Domingues, RM & Martha Antunes, LC 2019, 'The gut microbiome and metabolome of two riparian communities in the Amazon', Frontiers in Microbiology, vol. 10, 2003. https://doi.org/10.3389/fmicb.2019.02003

Standard

The gut microbiome and metabolome of two riparian communities in the Amazon. / Pires, Eder Soares; Pires Hardoim, Cristiane Cassiolato; Miranda, Karla Rodrigues; Secco, Danielle Angst; Lobo, Leandro Araujo; de Carvalho, Denise Pires; Han, Jun; Borchers, Christoph H.; Ferreira, Rosana B. R.; Salles, Joana Falcao; Cavalcanti Pilotto Domingues, Regina Maria; Martha Antunes, Luis Caetano.

In: Frontiers in Microbiology, Vol. 10, 2003, 04.09.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Pires ES, Pires Hardoim CC, Miranda KR, Secco DA, Lobo LA, de Carvalho DP et al. The gut microbiome and metabolome of two riparian communities in the Amazon. Frontiers in Microbiology. 2019 Sep 4;10. 2003. https://doi.org/10.3389/fmicb.2019.02003


BibTeX

@article{68b14b2295aa47328f54da341dfb5c8b,
title = "The gut microbiome and metabolome of two riparian communities in the Amazon",
abstract = "During the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they constitute a strong defense barrier to invading pathogens, and are also intricately linked to nutrition. The parameters that affect the establishment and maintenance of these microbial communities are diverse, and include the genetic background, mode of birth, nutrition, hygiene, and host lifestyle in general. Here, we describe the characterization of the gut microbiome of individuals living in the Amazon, and the comparison of these microbial communities to those found in individuals from an urban, industrialized setting. Our results showed striking differences in microbial communities from these two types of populations. Additionally, we used high-throughput metabolomics to study the chemical ecology of the gut environment and found significant metabolic changes between the two populations. Although we cannot point out a single cause for the microbial and metabolic changes observed between Amazonian and urban individuals, they are likely to include dietary differences as well as diverse patterns of environmental exposure. To our knowledge, this is the first description of gut microbial and metabolic profiles in Amazonian populations, and it provides a starting point for thorough characterizations of the impact of individual environmental conditions on the human microbiome and metabolome.",
keywords = "gut microbiome, riparian communities, Amazon, high-throughput sequencing, metabolic prediction, metabolomics, ENTEROTYPES, CORE",
author = "Pires, {Eder Soares} and {Pires Hardoim}, {Cristiane Cassiolato} and Miranda, {Karla Rodrigues} and Secco, {Danielle Angst} and Lobo, {Leandro Araujo} and {de Carvalho}, {Denise Pires} and Jun Han and Borchers, {Christoph H.} and Ferreira, {Rosana B. R.} and Salles, {Joana Falcao} and {Cavalcanti Pilotto Domingues}, {Regina Maria} and {Martha Antunes}, {Luis Caetano}",
year = "2019",
month = "9",
day = "4",
doi = "10.3389/fmicb.2019.02003",
language = "English",
volume = "10",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - The gut microbiome and metabolome of two riparian communities in the Amazon

AU - Pires, Eder Soares

AU - Pires Hardoim, Cristiane Cassiolato

AU - Miranda, Karla Rodrigues

AU - Secco, Danielle Angst

AU - Lobo, Leandro Araujo

AU - de Carvalho, Denise Pires

AU - Han, Jun

AU - Borchers, Christoph H.

AU - Ferreira, Rosana B. R.

AU - Salles, Joana Falcao

AU - Cavalcanti Pilotto Domingues, Regina Maria

AU - Martha Antunes, Luis Caetano

PY - 2019/9/4

Y1 - 2019/9/4

N2 - During the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they constitute a strong defense barrier to invading pathogens, and are also intricately linked to nutrition. The parameters that affect the establishment and maintenance of these microbial communities are diverse, and include the genetic background, mode of birth, nutrition, hygiene, and host lifestyle in general. Here, we describe the characterization of the gut microbiome of individuals living in the Amazon, and the comparison of these microbial communities to those found in individuals from an urban, industrialized setting. Our results showed striking differences in microbial communities from these two types of populations. Additionally, we used high-throughput metabolomics to study the chemical ecology of the gut environment and found significant metabolic changes between the two populations. Although we cannot point out a single cause for the microbial and metabolic changes observed between Amazonian and urban individuals, they are likely to include dietary differences as well as diverse patterns of environmental exposure. To our knowledge, this is the first description of gut microbial and metabolic profiles in Amazonian populations, and it provides a starting point for thorough characterizations of the impact of individual environmental conditions on the human microbiome and metabolome.

AB - During the last decades it has become increasingly clear that the microbes that live on and in humans are critical for health. The communities they form, termed microbiomes, are involved in fundamental processes such as the maturation and constant regulation of the immune system. Additionally, they constitute a strong defense barrier to invading pathogens, and are also intricately linked to nutrition. The parameters that affect the establishment and maintenance of these microbial communities are diverse, and include the genetic background, mode of birth, nutrition, hygiene, and host lifestyle in general. Here, we describe the characterization of the gut microbiome of individuals living in the Amazon, and the comparison of these microbial communities to those found in individuals from an urban, industrialized setting. Our results showed striking differences in microbial communities from these two types of populations. Additionally, we used high-throughput metabolomics to study the chemical ecology of the gut environment and found significant metabolic changes between the two populations. Although we cannot point out a single cause for the microbial and metabolic changes observed between Amazonian and urban individuals, they are likely to include dietary differences as well as diverse patterns of environmental exposure. To our knowledge, this is the first description of gut microbial and metabolic profiles in Amazonian populations, and it provides a starting point for thorough characterizations of the impact of individual environmental conditions on the human microbiome and metabolome.

KW - gut microbiome

KW - riparian communities

KW - Amazon

KW - high-throughput sequencing

KW - metabolic prediction

KW - metabolomics

KW - ENTEROTYPES

KW - CORE

U2 - 10.3389/fmicb.2019.02003

DO - 10.3389/fmicb.2019.02003

M3 - Article

VL - 10

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

M1 - 2003

ER -

ID: 97345723