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The Effects of Urbanization on the Infant Gut Microbiota and Health Outcomes
Brushett, S., Sinha, T., Reijneveld, S. A., de Kroon, M. L. A. & Zhernakova, A., 29-Jul-2020, In : Frontiers in Pediatrics. 8, p. 408 15 p., 408.Research output: Contribution to journal › Review article › Academic › peer-review
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The Effects of Urbanization on the Infant Gut Microbiota and Health Outcomes. / Brushett, Siobhan; Sinha, Trishla; Reijneveld, Sijmen A.; de Kroon, Marlou L. A.; Zhernakova, Alexandra.
In: Frontiers in Pediatrics, Vol. 8, 408, 29.07.2020, p. 408.Research output: Contribution to journal › Review article › Academic › peer-review
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TY - JOUR
T1 - The Effects of Urbanization on the Infant Gut Microbiota and Health Outcomes
AU - Brushett, Siobhan
AU - Sinha, Trishla
AU - Reijneveld, Sijmen A.
AU - de Kroon, Marlou L. A.
AU - Zhernakova, Alexandra
N1 - Copyright © 2020 Brushett, Sinha, Reijneveld, de Kroon and Zhernakova.
PY - 2020/7/29
Y1 - 2020/7/29
N2 - Humans and their gut microbiota have co-evolved over thousands of years, resulting in the establishment of a complex host-microbiota ecosystem. Early life environmental factors, such as delivery mode, nutrition, and medication use, have been shown to substantially affect both host-microbiota interactions and health outcomes. However, the effects of urbanization (characterized by the spectrum of rural and urban populations) on these early life events have been overlooked. A deeper understanding of the relationship between urbanization and microbiota development will allow for the identification of novel biological and social approaches that can be implemented to prevent and treat disease and promote maternal and infant/child health. The aim of this narrative review is to summarize how factors associated with urbanization differentially impact delivery mode, nutrition, and medication use, and how these changes subsequently affect the gut microbiota and health outcomes of infants. This narrative review also describes the important evidence gaps associated with these relationships and recommends actions that can be taken to improve the health of mothers and infants worldwide.
AB - Humans and their gut microbiota have co-evolved over thousands of years, resulting in the establishment of a complex host-microbiota ecosystem. Early life environmental factors, such as delivery mode, nutrition, and medication use, have been shown to substantially affect both host-microbiota interactions and health outcomes. However, the effects of urbanization (characterized by the spectrum of rural and urban populations) on these early life events have been overlooked. A deeper understanding of the relationship between urbanization and microbiota development will allow for the identification of novel biological and social approaches that can be implemented to prevent and treat disease and promote maternal and infant/child health. The aim of this narrative review is to summarize how factors associated with urbanization differentially impact delivery mode, nutrition, and medication use, and how these changes subsequently affect the gut microbiota and health outcomes of infants. This narrative review also describes the important evidence gaps associated with these relationships and recommends actions that can be taken to improve the health of mothers and infants worldwide.
KW - urbanization
KW - gut microbiota
KW - infant
KW - mother
KW - health outcomes
KW - delivery mode
KW - nutrition
KW - medication
KW - HUMAN-MILK MICROBIOME
KW - EXPOSED UNINFECTED INFANTS
KW - INTESTINAL MICROBIOTA
KW - CESAREAN-SECTIONS
KW - HERBAL MEDICINES
KW - MATERNAL WEIGHT
KW - LEVEL ANALYSIS
KW - HIV-INFECTION
KW - 1ST YEAR
KW - IMPACT
U2 - 10.3389/fped.2020.00408
DO - 10.3389/fped.2020.00408
M3 - Review article
C2 - 32903831
VL - 8
SP - 408
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
SN - 2296-2360
M1 - 408
ER -
ID: 133024074