Publication

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Fontana, L., Mitchell, S. E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D. S., Maissan, P., Speakman, J. R. & Demaria, M., Jun-2018, In : Aging Cell. 17, 3, 5 p., e12746.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

DOI

Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle-age human volunteers under CR in comparison with age-matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.

Original languageEnglish
Article numbere12746
Number of pages5
JournalAging Cell
Volume17
Issue number3
Early online date25-Mar-2018
Publication statusPublished - Jun-2018

    Keywords

  • ageing, aging, caloric restriction, cellular senescence, SASP, ADIPOSE-TISSUE, CELLS, SECRETION, DIET

View graph of relations

Download statistics

No data available

ID: 56087812