The discovery of new isocyanide-based multi-component reactions

Dömling, A., 1-Jun-2000, In : Current Opinion in Chemical Biology. 4, 3, p. 318-323 6 p.

Research output: Contribution to journalBook/Film/Article reviewProfessional

Multi-component reactions are finding increasing use in the discovery process of new drugs and agrochemicals. Some years ago they were considered as highly exotic types of organic reactions. Recently, many groups have realized that the field of multi-component reactions is full of new opportunities. These comprise fast and efficient production of small-molecular-weight compound libraries, highly atom-economic chemistry, very large chemical libraries, improvements in total synthesis, and applications in bioconjugate chemistry, as well as in related fields (e.g. chemical biology).
Original languageEnglish
Pages (from-to)318-323
Number of pages6
JournalCurrent Opinion in Chemical Biology
Issue number3
Publication statusPublished - 1-Jun-2000


  • alpha amino acid, benzodiazepine derivative, bleomycin, cystothiazole F, dihydroquinoline derivative, karnamycin B1, piperazine derivative, thiazole derivative, thiostrepton, tubulysine, unclassified drug, chemical reaction, drug research, drug screening, organic chemistry, review

ID: 25486936