Publication

The cytoskeleton regulates symmetry transitions in moving amoeboid cells

van Haastert, P. J. M., Keizer-Gunnink, I. & Kortholt, A., 9-Apr-2018, In : Journal of Cell Science. 131, 7, 35 p., UNSP jcs208892.

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Symmetry and symmetry breaking are essential in biology. Symmetry comes in different forms: rotational symmetry, mirror symmetry and alternating right/left symmetry. Especially the transitions between the different symmetry forms specify crucial points in cell biology, including gastrulation in development, formation of the cleavage furrow in cell division, or the front in cell polarity. However, the mechanisms of these symmetry transitions are not well understood. Here we have investigated the fundaments of symmetry and symmetry transitions of the cytoskeleton during cell movement. Our data show that the dynamic shape changes of amoeboid cells are far from random, but are the consequence of refined symmetries and symmetry changes that are orchestrated by small G-proteins and the cytoskeleton, with local stimulation by F-actin and Scar , and local inhibition by IQGAP2 and myosin.

Original languageEnglish
Article numberUNSP jcs208892
Number of pages35
JournalJournal of Cell Science
Volume131
Issue number7
Early online date27-Feb-2018
Publication statusPublished - 9-Apr-2018

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