Publication

The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response

Claassen-van Dessel, N., van der Wouden, J. C., Dekker, J., Rosmalen, J. G. M. & van der Horst, H. E., Aug-2017, In : Journal of Psychosomatic Research. 99, p. 130-136 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Claassen-van Dessel, N., van der Wouden, J. C., Dekker, J., Rosmalen, J. G. M., & van der Horst, H. E. (2017). The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response. Journal of Psychosomatic Research, 99, 130-136. https://doi.org/10.1016/j.jpsychores.2017.06.010

Author

Claassen-van Dessel, Nikki ; van der Wouden, Johannes C. ; Dekker, Joost ; Rosmalen, Judith G. M. ; van der Horst, Henriette E. / The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response. In: Journal of Psychosomatic Research. 2017 ; Vol. 99. pp. 130-136.

Harvard

Claassen-van Dessel, N, van der Wouden, JC, Dekker, J, Rosmalen, JGM & van der Horst, HE 2017, 'The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response', Journal of Psychosomatic Research, vol. 99, pp. 130-136. https://doi.org/10.1016/j.jpsychores.2017.06.010

Standard

The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response. / Claassen-van Dessel, Nikki; van der Wouden, Johannes C.; Dekker, Joost; Rosmalen, Judith G. M.; van der Horst, Henriette E.

In: Journal of Psychosomatic Research, Vol. 99, 08.2017, p. 130-136.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Claassen-van Dessel N, van der Wouden JC, Dekker J, Rosmalen JGM, van der Horst HE. The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response. Journal of Psychosomatic Research. 2017 Aug;99:130-136. https://doi.org/10.1016/j.jpsychores.2017.06.010


BibTeX

@article{b1fc0ca80dfb4e9789bfe297050d4847,
title = "The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response",
abstract = "Objectives: We aimed to assess the cross-sectional relation between levels of cortisol and specific symptom clusters, symptom severity and duration of symptoms in patients with medically unexplained physical symptoms (MUPS).Methods: Baseline data of a cohort of MUPS patients were used. We chose the Cortisol Awakening Response (CAR) as a cortisol parameter, using saliva samples. We used confirmatory factor analysis for the identification of 4 specific symptom clusters: (1) gastro-intestinal symptoms; (2) pain; (3) cardio-pulmonary symptoms; and (4) fatigue. For this factor analysis we used the Physical Symptom Questionnaire (PSQ), which assesses the occurrence and frequency of 51 physical symptoms. Symptom severity was measured with the Patient Health Questionnaire-15 (PHQ-15). Duration of symptoms was based on self-reported duration of top 3 symptoms. We performed multiple linear regression to assess relations between CAR and individual factor scores on symptom clusters, symptom severity and duration of symptoms.Results: Data from 296 patients (76{\%} female) were included in the analyses. The majority of patients suffered from symptoms in multiple organ systems. Factor analysis confirmed that the model with 4 symptom clusters fitted our data. For the total study population, we found no significant relation between CAR and participants' factor scores on any of the symptom clusters. We also found no significant relations between CAR and severity or duration of symptoms.Conclusion: Our results suggest that within a heterogeneous MUPS population there is no relation between CAR and symptom severity and duration. However, more studies are needed to confirm our findings.",
keywords = "Somatoform disorders, Hypothalamo-Hypophysial System, MUPS, Cortisol Awakening Response, FUNCTIONAL SOMATIC SYNDROMES, SOMATOFORM DISORDERS, SALIVARY CORTISOL, PRIMARY-CARE, HYPOCORTISOLISM, FIBROMYALGIA, INVENTORY, ANXIETY, DYSFUNCTION, POPULATION",
author = "{Claassen-van Dessel}, Nikki and {van der Wouden}, {Johannes C.} and Joost Dekker and Rosmalen, {Judith G. M.} and {van der Horst}, {Henriette E.}",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = "8",
doi = "10.1016/j.jpsychores.2017.06.010",
language = "English",
volume = "99",
pages = "130--136",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - The cross-sectional relation between medically unexplained physical symptoms (MUPS) and the Cortisol Awakening Response

AU - Claassen-van Dessel, Nikki

AU - van der Wouden, Johannes C.

AU - Dekker, Joost

AU - Rosmalen, Judith G. M.

AU - van der Horst, Henriette E.

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/8

Y1 - 2017/8

N2 - Objectives: We aimed to assess the cross-sectional relation between levels of cortisol and specific symptom clusters, symptom severity and duration of symptoms in patients with medically unexplained physical symptoms (MUPS).Methods: Baseline data of a cohort of MUPS patients were used. We chose the Cortisol Awakening Response (CAR) as a cortisol parameter, using saliva samples. We used confirmatory factor analysis for the identification of 4 specific symptom clusters: (1) gastro-intestinal symptoms; (2) pain; (3) cardio-pulmonary symptoms; and (4) fatigue. For this factor analysis we used the Physical Symptom Questionnaire (PSQ), which assesses the occurrence and frequency of 51 physical symptoms. Symptom severity was measured with the Patient Health Questionnaire-15 (PHQ-15). Duration of symptoms was based on self-reported duration of top 3 symptoms. We performed multiple linear regression to assess relations between CAR and individual factor scores on symptom clusters, symptom severity and duration of symptoms.Results: Data from 296 patients (76% female) were included in the analyses. The majority of patients suffered from symptoms in multiple organ systems. Factor analysis confirmed that the model with 4 symptom clusters fitted our data. For the total study population, we found no significant relation between CAR and participants' factor scores on any of the symptom clusters. We also found no significant relations between CAR and severity or duration of symptoms.Conclusion: Our results suggest that within a heterogeneous MUPS population there is no relation between CAR and symptom severity and duration. However, more studies are needed to confirm our findings.

AB - Objectives: We aimed to assess the cross-sectional relation between levels of cortisol and specific symptom clusters, symptom severity and duration of symptoms in patients with medically unexplained physical symptoms (MUPS).Methods: Baseline data of a cohort of MUPS patients were used. We chose the Cortisol Awakening Response (CAR) as a cortisol parameter, using saliva samples. We used confirmatory factor analysis for the identification of 4 specific symptom clusters: (1) gastro-intestinal symptoms; (2) pain; (3) cardio-pulmonary symptoms; and (4) fatigue. For this factor analysis we used the Physical Symptom Questionnaire (PSQ), which assesses the occurrence and frequency of 51 physical symptoms. Symptom severity was measured with the Patient Health Questionnaire-15 (PHQ-15). Duration of symptoms was based on self-reported duration of top 3 symptoms. We performed multiple linear regression to assess relations between CAR and individual factor scores on symptom clusters, symptom severity and duration of symptoms.Results: Data from 296 patients (76% female) were included in the analyses. The majority of patients suffered from symptoms in multiple organ systems. Factor analysis confirmed that the model with 4 symptom clusters fitted our data. For the total study population, we found no significant relation between CAR and participants' factor scores on any of the symptom clusters. We also found no significant relations between CAR and severity or duration of symptoms.Conclusion: Our results suggest that within a heterogeneous MUPS population there is no relation between CAR and symptom severity and duration. However, more studies are needed to confirm our findings.

KW - Somatoform disorders

KW - Hypothalamo-Hypophysial System

KW - MUPS

KW - Cortisol Awakening Response

KW - FUNCTIONAL SOMATIC SYNDROMES

KW - SOMATOFORM DISORDERS

KW - SALIVARY CORTISOL

KW - PRIMARY-CARE

KW - HYPOCORTISOLISM

KW - FIBROMYALGIA

KW - INVENTORY

KW - ANXIETY

KW - DYSFUNCTION

KW - POPULATION

U2 - 10.1016/j.jpsychores.2017.06.010

DO - 10.1016/j.jpsychores.2017.06.010

M3 - Article

VL - 99

SP - 130

EP - 136

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

ER -

ID: 46830101