Publication

The combined use of enamel matrix proteins and a tetracycline-coated expanded polytetrafluoroethylene barrier membrane in the treatment of intra-osseous defects

Sipos, PM., Loos, BG., Abbas, F., Timmerman, MF. & van der Velden, U., Jul-2005, In : Journal of Clinical Periodontology. 32, 7, p. 765-772 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • PM Sipos
  • BG Loos
  • F Abbas
  • MF Timmerman
  • U van der Velden

Objectives: The purpose of this split-mouth study was to evaluate the clinical response of enamel matrix proteins (EMPs, Emdogain Gel((R))) in intra-osseous defects with or without a combined application of a tetracycline-coated expanded polytetrafluoroethylene barrier membrane (e-PTFE, Gore-Tex((R))).

Methods: Twelve pairs of intra-osseous periodontal defects in 11 patients received the application of EMPs on the exposed root surface (EMP). One of the two defects received randomly, as an adjunct to EMP treatment, a tetracycline-coated e-PTFE membrane (MEMP). At baseline, 6- and 12-month probing pocket depth (PPD), clinical attachment level (CAL) and probing bone level (PBL) were measured.

Results: After 12 months, the EMP defects showed a significant mean PPD reduction of 2.86 +/- 0.75 mm, a mean gain in CAL of 1.28 +/- 2.04 mm, a mean PBL gain of 1.63 +/- 1.21 mm and a mean increase of recession (REC) of 1.56 +/- 2.30 mm. The MEMP defects showed a significant mean PPD reduction of 3.02 +/- 1.55 mm, a mean gain in CAL of 1.65 +/- 1.29 mm, a mean PBL gain of 1.58 +/- 1.92 mm and a mean increase of REC of 1.38 +/- 1.63 mm. Except for significantly more post-operative discomfort at the MEMP sites, no significant differences were found between EMP and MEMP defects.

Conclusion: Within the limits of this study, it is concluded that in the treatment of intra-osseous defects with EMP, the adjunctive use of a tetracycline-coated e-PTFE membrane failed to show more gain of CAL and PBL.

Original languageEnglish
Pages (from-to)765-772
Number of pages8
JournalJournal of Clinical Periodontology
Volume32
Issue number7
Publication statusPublished - Jul-2005

    Keywords

  • barrier membranes, enamel matrix proteins, GTR, intra-osseous defects, tetracycline, GUIDED TISSUE REGENERATION, INTRABONY PERIODONTAL DEFECTS, CONTROLLED CLINICAL-TRIAL, NON-RESORBABLE BARRIERS, ANGULAR BONE DEFECTS, IN-VITRO, BIOABSORBABLE MEMBRANES, DERIVATIVE EMDOGAIN(R), BACTERIAL-COLONIZATION, ANAEROBIC-BACTERIA

ID: 4341262