Publication

The Cascade of Stress: A Network Approach to Explore Differential Dynamics in Populations Varying in Risk for Psychosis

Klippel, A., Viechtbauer, W., Reininghaus, U., Wigman, J., van Borkulo, C., Myin-Germeys, I., Wichers, M. & MERGE, 15-Feb-2018, In : Schizophrenia Bulletin. 44, 2, p. 328-337 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

DOI

Stress plays a central role in the development and persistence of psychosis. Network analysis may help to reveal mechanisms at the level of the micro-dynamic effects between stress, other daily experiences and symptomatology. This is the first study to examine time-lagged networks of the relations between minor daily stress, momentary affect/thoughts, psychotic experiences, and other potentially relevant daily life contexts in individuals varying in risk for psychosis. Intensive longitudinal data were obtained through 6 studies. The combined sample consisted of 654 individuals varying in risk for psychosis: healthy control subjects (n = 244), first-degree relatives of psychotic patients (n = 165), and psychotic patients (n = 245). Using multilevel models combined with permutation testing, group-specific time-lagged network connections between daily experiences were compared between groups. Specifically, the role of stress was examined. Risk for psychosis was related to a higher number of significant network connections. In all populations, stress had a central position in the network and showed direct and significant connections with subsequent psychotic experiences. Furthermore, the higher the risk for psychosis, the more variables "loss of control" and "suspicious" were susceptible to influences by other network nodes. These findings support the idea that minor daily stress may play an important role in inducing a cascade of effects that may lead to psychotic experiences.

Original languageEnglish
Pages (from-to)328-337
Number of pages10
JournalSchizophrenia Bulletin
Volume44
Issue number2
Early online dateMar-2017
Publication statusPublished - 15-Feb-2018

    Keywords

  • Journal Article, EXPERIENCES, INTERPLAY, DAILY-LIFE STRESS, AFFECTIVE PATHWAY, CHILDHOOD TRAUMA, REACTIVITY, SCHIZOPHRENIA, DISORDER, INDIVIDUALS, PERSPECTIVE

View graph of relations

Download statistics

No data available

ID: 41472291