Publication

The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU

Maurer, M., Abuzakouk, M., Berard, F., Canonica, W., Elberink, H. O., Gimenez-Arnau, A., Grattan, C., Hollis, K., Knulst, A., Lacour, J-P., Lynde, C., Marsland, A., McBride, D., Nakonechna, A., Ortiz de Frutos, J., Proctor, C., Sussman, G., Sweeney, C., Tian, H., Weller, K., Wolin, D. & Balp, M-M. Dec-2017 In : Allergy. 72, 12, p. 2005-2016 12 p.

Research output: Contribution to journalArticle

  • M. Maurer
  • M. Abuzakouk
  • F. Berard
  • W. Canonica
  • H. Oude Elberink
  • A. Gimenez-Arnau
  • C. Grattan
  • K. Hollis
  • A. Knulst
  • J-P Lacour
  • C. Lynde
  • A. Marsland
  • D. McBride
  • A. Nakonechna
  • J. Ortiz de Frutos
  • C. Proctor
  • G. Sussman
  • C. Sweeney
  • H. Tian
  • K. Weller
  • D. Wolin
  • M-M. Balp

Background: Chronic spontaneous urticaria (CSU) can be debilitating, difficult to treat, and frustrating for patients and physicians. Real-world evidence for the burden of CSU is limited. The objective of this study was to document disease duration, treatment history, and disease activity, as well as impact on health-related quality of life (HRQoL) and work among patients with inadequately controlled CSU, and to describe its humanistic, societal, and economic burden.

Methods: This international observational study assessed a cohort of 673 adult patients with CSU whose symptoms persisted for 12 months despite treatment. Demographics, disease characteristics, and healthcare resource use in the previous 12 months were collected from medical records. Patient-reported data on urticaria and angioedema symptoms, HRQoL, and work productivity and activity impairment were collected from a survey and a diary.

Results: Almost 50% of patients had moderate-to-severe disease activity as reported by Urticaria Activity Score. Mean (SD) Dermatology Life Quality Index and Chronic Urticaria Quality of Life Questionnaire scores were 9.1 (6.62) and 33.6 (20.99), respectively. Chronic spontaneous urticaria markedly interfered with sleep and daily activities. Angioedema in the previous 12 months was reported by 66% of enrolled patients and significantly affected HRQoL. More than 20% of patients reported 1 hour per week of missed work; productivity impairment was 27%. These effects increased with increasing disease activity. Significant healthcare resources and costs were incurred to treat CSU.

Conclusions: Chronic spontaneous urticaria has considerable humanistic and economic impacts. Patients with greater disease activity and with angioedema experience greater HRQoL impairments.

Original languageEnglish
Pages (from-to)2005-2016
Number of pages12
JournalAllergy
Volume72
Issue number12
StatePublished - Dec-2017

    Keywords

  • angioedema, economic burden, observational study, quality of life, urticaria, CHRONIC IDIOPATHIC URTICARIA, QUALITY-OF-LIFE, TASK-FORCE REPORT, HEALTH-CARE, COST-EFFECTIVENESS, DISEASE SEVERITY, RESOURCE USE, DAILY DIARY, INDEX DLQI, IMPACT

View graph of relations

Download statistics

No data available

ID: 52165805