Publication

The brain's best friend: microglial neurotoxicity revisited

Hellwig, S., Heinrich, A. & Biber, K., 16-May-2013, In : Frontiers in cellular neuroscience. 7, 11 p., 71.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Hellwig, S., Heinrich, A., & Biber, K. (2013). The brain's best friend: microglial neurotoxicity revisited. Frontiers in cellular neuroscience, 7, [71]. https://doi.org/10.3389/fncel.2013.00071

Author

Hellwig, Sabine ; Heinrich, Annette ; Biber, Knut. / The brain's best friend : microglial neurotoxicity revisited. In: Frontiers in cellular neuroscience. 2013 ; Vol. 7.

Harvard

Hellwig, S, Heinrich, A & Biber, K 2013, 'The brain's best friend: microglial neurotoxicity revisited', Frontiers in cellular neuroscience, vol. 7, 71. https://doi.org/10.3389/fncel.2013.00071

Standard

The brain's best friend : microglial neurotoxicity revisited. / Hellwig, Sabine; Heinrich, Annette; Biber, Knut.

In: Frontiers in cellular neuroscience, Vol. 7, 71, 16.05.2013.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Hellwig S, Heinrich A, Biber K. The brain's best friend: microglial neurotoxicity revisited. Frontiers in cellular neuroscience. 2013 May 16;7. 71. https://doi.org/10.3389/fncel.2013.00071


BibTeX

@article{a48a4f5a11f2417788bae9672c461802,
title = "The brain's best friend: microglial neurotoxicity revisited",
abstract = "One long standing aspect of microglia biology was never questioned; their involvement in brain disease. Based on morphological changes (retracted processes and amoeboid shape) that inevitably occur in these cells in case of damage in the central nervous system, microglia in the diseased brain were called {"}activated.{"} Because {"}activated{"} microglia were always found in direct neighborhood to dead or dying neuron, and since it is known now for more than 20 years that cultured microglia release numerous factors that are able to kill neurons, microglia {"}activation{"} was often seen as a neurotoxic process. From an evolutionary point of view, however, it is difficult to understand why an important, mostly post-mitotic and highly vulnerable organ like the brain would host numerous potential killers. This review is aimed to critically reconsider the term microglia neurotoxicity and to discuss experimental problems around microglia biology, that often have led to the conclusion that microglia are neurotoxic cells.",
keywords = "microglia, neuroprotection, mouse models, innate immunity, CX3CR1, microglia depletion, HIPPOCAMPAL SLICE CULTURES, CENTRAL-NERVOUS-SYSTEM, AMYOTROPHIC-LATERAL-SCLEROSIS, FOCAL CEREBRAL-ISCHEMIA, MONOCYTE CHEMOATTRACTANT PROTEIN-1, CHEMOKINE RECEPTOR CCR2, INNATE IMMUNE-RESPONSE, BORNE CELL RECRUITMENT, CNS MYELOID CELLS, NEUROPATHIC PAIN",
author = "Sabine Hellwig and Annette Heinrich and Knut Biber",
year = "2013",
month = "5",
day = "16",
doi = "10.3389/fncel.2013.00071",
language = "English",
volume = "7",
journal = "Frontiers in cellular neuroscience",
issn = "1662-5102",
publisher = "Frontiers Media SA",

}

RIS

TY - JOUR

T1 - The brain's best friend

T2 - microglial neurotoxicity revisited

AU - Hellwig, Sabine

AU - Heinrich, Annette

AU - Biber, Knut

PY - 2013/5/16

Y1 - 2013/5/16

N2 - One long standing aspect of microglia biology was never questioned; their involvement in brain disease. Based on morphological changes (retracted processes and amoeboid shape) that inevitably occur in these cells in case of damage in the central nervous system, microglia in the diseased brain were called "activated." Because "activated" microglia were always found in direct neighborhood to dead or dying neuron, and since it is known now for more than 20 years that cultured microglia release numerous factors that are able to kill neurons, microglia "activation" was often seen as a neurotoxic process. From an evolutionary point of view, however, it is difficult to understand why an important, mostly post-mitotic and highly vulnerable organ like the brain would host numerous potential killers. This review is aimed to critically reconsider the term microglia neurotoxicity and to discuss experimental problems around microglia biology, that often have led to the conclusion that microglia are neurotoxic cells.

AB - One long standing aspect of microglia biology was never questioned; their involvement in brain disease. Based on morphological changes (retracted processes and amoeboid shape) that inevitably occur in these cells in case of damage in the central nervous system, microglia in the diseased brain were called "activated." Because "activated" microglia were always found in direct neighborhood to dead or dying neuron, and since it is known now for more than 20 years that cultured microglia release numerous factors that are able to kill neurons, microglia "activation" was often seen as a neurotoxic process. From an evolutionary point of view, however, it is difficult to understand why an important, mostly post-mitotic and highly vulnerable organ like the brain would host numerous potential killers. This review is aimed to critically reconsider the term microglia neurotoxicity and to discuss experimental problems around microglia biology, that often have led to the conclusion that microglia are neurotoxic cells.

KW - microglia

KW - neuroprotection

KW - mouse models

KW - innate immunity

KW - CX3CR1

KW - microglia depletion

KW - HIPPOCAMPAL SLICE CULTURES

KW - CENTRAL-NERVOUS-SYSTEM

KW - AMYOTROPHIC-LATERAL-SCLEROSIS

KW - FOCAL CEREBRAL-ISCHEMIA

KW - MONOCYTE CHEMOATTRACTANT PROTEIN-1

KW - CHEMOKINE RECEPTOR CCR2

KW - INNATE IMMUNE-RESPONSE

KW - BORNE CELL RECRUITMENT

KW - CNS MYELOID CELLS

KW - NEUROPATHIC PAIN

U2 - 10.3389/fncel.2013.00071

DO - 10.3389/fncel.2013.00071

M3 - Review article

C2 - 23734099

VL - 7

JO - Frontiers in cellular neuroscience

JF - Frontiers in cellular neuroscience

SN - 1662-5102

M1 - 71

ER -

ID: 5864524