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The birth of yeast peroxisomes

Yuan, W., Veenhuis, M. & van der Klei, I. J., May-2016, In : Biochimica et biophysica acta. 1863, 5, p. 902-910 9 p., 17661.

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  • The birth of yeast peroxisomes

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DOI

This contribution describes the phenotypic differences of yeast peroxisome-deficient mutants (pex mutants). In some cases different phenotypes were reported for yeast mutants deleted in the same PEX gene. These differences are most likely related to the marker proteins and methods used to detect peroxisomal remnants. This is especially evident for pex3 and pex19 mutants, where the localization of receptor docking proteins (Pex13, Pex14) resulted in the identification of peroxisomal membrane remnants, which do not contain other peroxisomal membrane proteins, such as the ring proteins Pex2, Pex10 and Pex12. These structures in pex3 and pex19 cells are the template for peroxisome formation upon introduction of the missing gene. Taken together, these data suggest that in all yeast pex mutants analyzed so far peroxisomes are not formed de novo but use membrane remnant structures as a template for peroxisome formation upon reintroduction of the missing gene. The relevance of this model for peroxisomal membrane protein and lipid sorting to peroxisomes is discussed. This article is part of a Special Issue entitled: Peroxisomes.

Original languageEnglish
Article number17661
Pages (from-to)902-910
Number of pages9
JournalBiochimica et biophysica acta
Volume1863
Issue number5
Publication statusPublished - May-2016

    Keywords

  • Peroxisome, Peroxisome-deficient mutant, peroxisomal membrane protein, Membrane, lipids, membrane contact sites

ID: 23823590