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THE ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR PERINDOPRIL IMPROVES SURVIVAL AFTER EXPERIMENTAL MYOCARDIAL-INFARCTION IN PIGS

TOBE, TJM., DELANGEN, CDJ., WEERSINK, EGL., VANWIJNGAARDEN, J., BEL, KJ., DEGRAEFF, PA., VANGILST, WH. & WESSELING, H., May-1992, In : Journal of Cardiovascular Pharmacology. 19, 5, p. 732-740 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

In this randomized, blinded study the effect of the angiotensin converting enzyme inhibitor perindopril on electrical stability after myocardial infarction in pigs was compared to placebo. The left anterior descending artery was occluded for 45 min. Perindoprilat (0.06 mg/kg, n = 12) or saline (n = 12) was injected 15 min before reperfusion. Treatment was continued till day 13 with perindopril (12 mg, once daily) or placebo. At day 14 an electrophysiologic study was performed. The release of creatine phosphokinase did not differ significantly. During the subsequent days, seven of 12 placebo-treated pigs died (six within 24 h), whereas two of the 12 perindopril-treated pigs died (one within 24 h; p <0.04). Sustained ventricular tachycardia was inducible in one of five placebo-treated pigs versus three of 10 perindopril-treated survivors (NS). Late potentials had developed in one placebo-treated pig but not in pigs that received perindopril. Characteristics of infarct border zone heterogeneity (percentages of a reference electrode in viable myocardium) such as dispersion of current thresholds (127 +/- 96 vs. 238 +/- 463% in perindopril-treated pigs, NS) and refractoriness (9.8 +/- 8.4 vs. 11.9 +/- 6.0% in perindopril-treated pigs, NS) were comparable. This treatment with perindopril significantly improved survival while electrical stability was comparable between survivors. The latter indicates that a comparable electrical stability 2 weeks after myocardial infarction is obtained in perindopril-treated pigs at a significantly higher survival rate.

Original languageEnglish
Pages (from-to)732-740
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume19
Issue number5
Publication statusPublished - May-1992

    Keywords

  • PERINDOPRIL, EXPERIMENTAL MYOCARDIAL INFARCTION, ACE INHIBITION, ARRHYTHMIAS, SURVIVAL, ELECTROPHYSIOLOGY, VENTRICULAR-TACHYCARDIA, HEART-FAILURE, PROGNOSTIC-SIGNIFICANCE, DOUBLE-BLIND, CAPTOPRIL, RENIN, RADIOIMMUNOASSAY, REPERFUSION, ARRHYTHMIAS, STIMULATION

ID: 6314010