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The adverse drug reaction reporting assignment for specialist oncology nurses: a preliminary evaluation of quality, relevance and educational value in a prospective cohort study

Schutte, T., van Eekeren, R., Richir, M., van Staveren, J., van Puijenbroek, E., Tichelaar, J. & van Agtmael, M., Jan-2018, In : Naunyn-Schmiedebergs Archives of Pharmacology. 391, 1, p. 17-26 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Tim Schutte
  • Rike van Eekeren
  • Milan Richir
  • Jojanneke van Staveren
  • Eugène van Puijenbroek
  • Jelle Tichelaar
  • Michiel van Agtmael

In a new prescribing qualification course for specialist oncology nurses, we thought that it is important to emphasize pharmacovigilance and adverse drug reaction (ADR) reporting. We aimed to develop and evaluate an ADR reporting assignment for specialist oncology nurses. The quality of report documentation was assessed with the "Clinical Documentation tool to assess Individual Case Safety Reports" (ClinDoc). The relevance of the reports was evaluated in terms of ADR seriousness, the listing for additional monitoring of the drug by European Medicines Agency (EMA), and lack of labelling information about the ADR. Nurses' opinions of the assignment were evaluated using an E-survey. Thirty-three ADRs were reported, 32 (97%) of which were well documented according to ClinDoc. Thirteen ADRs (39%) were "serious" according to CIOMS criteria. In five cases (15%), the suspect drugs were listed for additional monitoring by EMA and in seven cases (21%), the ADR was not mentioned in the Summary of Product Characteristics. Twenty-five (78.1%) of the 32 enrolled nurses completed the E-survey. Most were > 45 years of age (68%), female (92%) and had extensive clinical experience (6-33 years). All agreed or completely agreed that the reporting assignment was useful, that it fitted in daily practice and that it increased their attention for medication/patient safety. A large majority (84.0%) agreed the assignment changed how they dealt with ADRs. Specialist oncology nurses are capable of reporting ADRs, and they considered the assignment useful. The assignment yielded valuable, relevant, and well-documented ADR reports for pharmacovigilance practice.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalNaunyn-Schmiedebergs Archives of Pharmacology
Volume391
Issue number1
Early online date23-Oct-2017
Publication statusPublished - Jan-2018

    Keywords

  • Journal Article, DOCTORS, EVENTS, HEALTH-CARE PROFESSIONALS, MEDICAL-STUDENTS, PHARMACOVIGILANCE, ATTITUDES, DOCUMENTATION, FEASIBILITY, INFORMATION

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