Publication

The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study

Govaert, G. A. M., Hobbelink, M. G. G., Reininga, I. H. F., Bosch, P., Kwee, T. C., de Jong, P. A., Jutte, P. C., Vogely, H. C., Dierckx, R. A. J. O., Leenen, L. P. H., Glaudemans, A. W. J. M. & IJpma, F. F. A., Sep-2019, In : BMJ Open. 9, 9, 7 p., 027772.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Govaert, G. A. M., Hobbelink, M. G. G., Reininga, I. H. F., Bosch, P., Kwee, T. C., de Jong, P. A., ... IJpma, F. F. A. (2019). The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study. BMJ Open, 9(9), [027772]. https://doi.org/10.1136/bmjopen-2018-027772

Author

Govaert, G. A. M. ; Hobbelink, M. G. G. ; Reininga, I. H. F. ; Bosch, P. ; Kwee, T. C. ; de Jong, P. A. ; Jutte, P. C. ; Vogely, H. C. ; Dierckx, R. A. J. O. ; Leenen, L. P. H. ; Glaudemans, A. W. J. M. ; IJpma, F. F. A. / The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial : study protocol for a prospective multicenter cohort study. In: BMJ Open. 2019 ; Vol. 9, No. 9.

Harvard

Govaert, GAM, Hobbelink, MGG, Reininga, IHF, Bosch, P, Kwee, TC, de Jong, PA, Jutte, PC, Vogely, HC, Dierckx, RAJO, Leenen, LPH, Glaudemans, AWJM & IJpma, FFA 2019, 'The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study', BMJ Open, vol. 9, no. 9, 027772. https://doi.org/10.1136/bmjopen-2018-027772

Standard

The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial : study protocol for a prospective multicenter cohort study. / Govaert, G. A. M.; Hobbelink, M. G. G.; Reininga, I. H. F.; Bosch, P.; Kwee, T. C.; de Jong, P. A.; Jutte, P. C.; Vogely, H. C.; Dierckx, R. A. J. O.; Leenen, L. P. H.; Glaudemans, A. W. J. M.; IJpma, F. F. A.

In: BMJ Open, Vol. 9, No. 9, 027772, 09.2019.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Govaert GAM, Hobbelink MGG, Reininga IHF, Bosch P, Kwee TC, de Jong PA et al. The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study. BMJ Open. 2019 Sep;9(9). 027772. https://doi.org/10.1136/bmjopen-2018-027772


BibTeX

@article{3ede3422bff241f59b194ccf9dc86143,
title = "The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study",
abstract = "Introduction The optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.Methods and analysis This study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligible for inclusion. Patients will undergo all three investigational imaging procedures (WBC scintigraphy, FDG-PET and MRI) within a time frame of 14 days after inclusion. The reference standard will be the result of at least five intraoperative sampled microbiology cultures, or, in case of no surgery, the clinical presence or absence of infection at 1 year follow-up. Initially, the results of all three imaging modalities will be available to the treating team as per local protocol. At a later time point, all scans will be centrally reassessed by nuclear medicine physicians and radiologists who are blinded for the identity of the patients and their clinical outcome. The discriminative ability of the imaging modalities will be quantified by several measures of diagnostic accuracy.Ethics and dissemination Approval of the study by the Institutional Review Board has been obtained prior to the start of this study. The results of this trial will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at scientific meetings and data sharing with other investigators through academically established means.",
keywords = "SURGERY, ORTHOPAEDIC & TRAUMA SURGERY, RADIOLOGY & IMAGING, NUCLEAR MEDICINE, MICROBIOLOGY, Limb reconstruction, OSTEOMYELITIS, EPIDEMIOLOGY, PET/CT",
author = "Govaert, {G. A. M.} and Hobbelink, {M. G. G.} and Reininga, {I. H. F.} and P. Bosch and Kwee, {T. C.} and {de Jong}, {P. A.} and Jutte, {P. C.} and Vogely, {H. C.} and Dierckx, {R. A. J. O.} and Leenen, {L. P. H.} and Glaudemans, {A. W. J. M.} and IJpma, {F. F. A.}",
year = "2019",
month = "9",
doi = "10.1136/bmjopen-2018-027772",
language = "English",
volume = "9",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial

T2 - study protocol for a prospective multicenter cohort study

AU - Govaert, G. A. M.

AU - Hobbelink, M. G. G.

AU - Reininga, I. H. F.

AU - Bosch, P.

AU - Kwee, T. C.

AU - de Jong, P. A.

AU - Jutte, P. C.

AU - Vogely, H. C.

AU - Dierckx, R. A. J. O.

AU - Leenen, L. P. H.

AU - Glaudemans, A. W. J. M.

AU - IJpma, F. F. A.

PY - 2019/9

Y1 - 2019/9

N2 - Introduction The optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.Methods and analysis This study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligible for inclusion. Patients will undergo all three investigational imaging procedures (WBC scintigraphy, FDG-PET and MRI) within a time frame of 14 days after inclusion. The reference standard will be the result of at least five intraoperative sampled microbiology cultures, or, in case of no surgery, the clinical presence or absence of infection at 1 year follow-up. Initially, the results of all three imaging modalities will be available to the treating team as per local protocol. At a later time point, all scans will be centrally reassessed by nuclear medicine physicians and radiologists who are blinded for the identity of the patients and their clinical outcome. The discriminative ability of the imaging modalities will be quantified by several measures of diagnostic accuracy.Ethics and dissemination Approval of the study by the Institutional Review Board has been obtained prior to the start of this study. The results of this trial will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at scientific meetings and data sharing with other investigators through academically established means.

AB - Introduction The optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.Methods and analysis This study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligible for inclusion. Patients will undergo all three investigational imaging procedures (WBC scintigraphy, FDG-PET and MRI) within a time frame of 14 days after inclusion. The reference standard will be the result of at least five intraoperative sampled microbiology cultures, or, in case of no surgery, the clinical presence or absence of infection at 1 year follow-up. Initially, the results of all three imaging modalities will be available to the treating team as per local protocol. At a later time point, all scans will be centrally reassessed by nuclear medicine physicians and radiologists who are blinded for the identity of the patients and their clinical outcome. The discriminative ability of the imaging modalities will be quantified by several measures of diagnostic accuracy.Ethics and dissemination Approval of the study by the Institutional Review Board has been obtained prior to the start of this study. The results of this trial will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at scientific meetings and data sharing with other investigators through academically established means.

KW - SURGERY

KW - ORTHOPAEDIC & TRAUMA SURGERY

KW - RADIOLOGY & IMAGING

KW - NUCLEAR MEDICINE

KW - MICROBIOLOGY

KW - Limb reconstruction

KW - OSTEOMYELITIS

KW - EPIDEMIOLOGY

KW - PET/CT

U2 - 10.1136/bmjopen-2018-027772

DO - 10.1136/bmjopen-2018-027772

M3 - Article

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 9

M1 - 027772

ER -

ID: 108332341