Publication

Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based study

van Maaren, M. C., de Munck, L., Strobbe, L. J. A., Sonke, G. S., Westenend, P. J., Smidt, M. L., Poortmans, P. M. P. & Siesling, S., 15-Jan-2019, In : International Journal of Cancer. 144, 2, p. 263-272 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van Maaren, M. C., de Munck, L., Strobbe, L. J. A., Sonke, G. S., Westenend, P. J., Smidt, M. L., ... Siesling, S. (2019). Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based study. International Journal of Cancer, 144(2), 263-272. https://doi.org/10.1002/ijc.31914

Author

van Maaren, Marissa C. ; de Munck, Linda ; Strobbe, Luc J. A. ; Sonke, Gabe S. ; Westenend, Pieter J. ; Smidt, Marjolein L. ; Poortmans, Philip M. P. ; Siesling, Sabine. / Ten-year recurrence rates for breast cancer subtypes in the Netherlands : A large population-based study. In: International Journal of Cancer. 2019 ; Vol. 144, No. 2. pp. 263-272.

Harvard

van Maaren, MC, de Munck, L, Strobbe, LJA, Sonke, GS, Westenend, PJ, Smidt, ML, Poortmans, PMP & Siesling, S 2019, 'Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based study', International Journal of Cancer, vol. 144, no. 2, pp. 263-272. https://doi.org/10.1002/ijc.31914

Standard

Ten-year recurrence rates for breast cancer subtypes in the Netherlands : A large population-based study. / van Maaren, Marissa C.; de Munck, Linda; Strobbe, Luc J. A.; Sonke, Gabe S.; Westenend, Pieter J.; Smidt, Marjolein L.; Poortmans, Philip M. P.; Siesling, Sabine.

In: International Journal of Cancer, Vol. 144, No. 2, 15.01.2019, p. 263-272.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van Maaren MC, de Munck L, Strobbe LJA, Sonke GS, Westenend PJ, Smidt ML et al. Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based study. International Journal of Cancer. 2019 Jan 15;144(2):263-272. https://doi.org/10.1002/ijc.31914


BibTeX

@article{930303215a644461bc388c832aa9a148,
title = "Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based study",
abstract = "Here we report for the first time the relation between breast cancer subtypes and 10-year recurrence rates and mortality in the Netherlands. All operated women diagnosed with invasive non-metastatic breast cancer in 2005 in the Netherlands were included. Patients were classified into breast cancer subtypes according to ER, PR, HER2 status and grade: luminal A, luminal B, HER2 positive and triple negative. Percentages and hazards of recurrence were compared among subtypes. Adjusted 10-year overall (OS) and recurrence-free survival (RFS) were calculated using multivariable Cox regression. Of 8,062 patients, 4,482 (56{\%}) were luminal A, 2,090 (26{\%}) luminal B, 504 (6{\%}) HER2 positive and 986 (12{\%}) triple negative. Local recurrences (7.5{\%}) and distant metastases (25.6{\%}) occurred most often in HER2 positive disease and the least often in luminal A (3.7{\%} and 9.5{\%}, respectively). Regional recurrences were most often diagnosed in triple negative disease (5.2{\%}), and the least often in luminal A (1.7{\%}). HER2 positive and triple negative subtypes had the highest recurrence rates in the second year, while luminal A and B showed a more continuous pattern over time, with lobular tumours recurring more often. After adjustment for differences in baseline characteristics, triple negative disease showed worse 10-year OS and triple negative and HER2 positive disease had the lowest 10-year RFS. In the Netherlands, breast cancer subtypes are important predictors for 10-year recurrence rates. Knowledge on recurrence and survival rates according to these different subtypes, in combination with other prognostic factors, can support patient-tailored treatment and individualised follow-up.",
keywords = "breast cancer subtypes, breast cancer, recurrence, 10-year follow-up, population-based, hazard, MOLECULAR SUBTYPES, REGIONAL RECURRENCE, HISTOLOGICAL GRADE, ENDOCRINE THERAPY, EXPRESSION, RECEPTOR, IMPACT, RECOMMENDATIONS, CLASSIFICATION, PATTERNS",
author = "{van Maaren}, {Marissa C.} and {de Munck}, Linda and Strobbe, {Luc J. A.} and Sonke, {Gabe S.} and Westenend, {Pieter J.} and Smidt, {Marjolein L.} and Poortmans, {Philip M. P.} and Sabine Siesling",
year = "2019",
month = "1",
day = "15",
doi = "10.1002/ijc.31914",
language = "English",
volume = "144",
pages = "263--272",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "WILEY",
number = "2",

}

RIS

TY - JOUR

T1 - Ten-year recurrence rates for breast cancer subtypes in the Netherlands

T2 - A large population-based study

AU - van Maaren, Marissa C.

AU - de Munck, Linda

AU - Strobbe, Luc J. A.

AU - Sonke, Gabe S.

AU - Westenend, Pieter J.

AU - Smidt, Marjolein L.

AU - Poortmans, Philip M. P.

AU - Siesling, Sabine

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Here we report for the first time the relation between breast cancer subtypes and 10-year recurrence rates and mortality in the Netherlands. All operated women diagnosed with invasive non-metastatic breast cancer in 2005 in the Netherlands were included. Patients were classified into breast cancer subtypes according to ER, PR, HER2 status and grade: luminal A, luminal B, HER2 positive and triple negative. Percentages and hazards of recurrence were compared among subtypes. Adjusted 10-year overall (OS) and recurrence-free survival (RFS) were calculated using multivariable Cox regression. Of 8,062 patients, 4,482 (56%) were luminal A, 2,090 (26%) luminal B, 504 (6%) HER2 positive and 986 (12%) triple negative. Local recurrences (7.5%) and distant metastases (25.6%) occurred most often in HER2 positive disease and the least often in luminal A (3.7% and 9.5%, respectively). Regional recurrences were most often diagnosed in triple negative disease (5.2%), and the least often in luminal A (1.7%). HER2 positive and triple negative subtypes had the highest recurrence rates in the second year, while luminal A and B showed a more continuous pattern over time, with lobular tumours recurring more often. After adjustment for differences in baseline characteristics, triple negative disease showed worse 10-year OS and triple negative and HER2 positive disease had the lowest 10-year RFS. In the Netherlands, breast cancer subtypes are important predictors for 10-year recurrence rates. Knowledge on recurrence and survival rates according to these different subtypes, in combination with other prognostic factors, can support patient-tailored treatment and individualised follow-up.

AB - Here we report for the first time the relation between breast cancer subtypes and 10-year recurrence rates and mortality in the Netherlands. All operated women diagnosed with invasive non-metastatic breast cancer in 2005 in the Netherlands were included. Patients were classified into breast cancer subtypes according to ER, PR, HER2 status and grade: luminal A, luminal B, HER2 positive and triple negative. Percentages and hazards of recurrence were compared among subtypes. Adjusted 10-year overall (OS) and recurrence-free survival (RFS) were calculated using multivariable Cox regression. Of 8,062 patients, 4,482 (56%) were luminal A, 2,090 (26%) luminal B, 504 (6%) HER2 positive and 986 (12%) triple negative. Local recurrences (7.5%) and distant metastases (25.6%) occurred most often in HER2 positive disease and the least often in luminal A (3.7% and 9.5%, respectively). Regional recurrences were most often diagnosed in triple negative disease (5.2%), and the least often in luminal A (1.7%). HER2 positive and triple negative subtypes had the highest recurrence rates in the second year, while luminal A and B showed a more continuous pattern over time, with lobular tumours recurring more often. After adjustment for differences in baseline characteristics, triple negative disease showed worse 10-year OS and triple negative and HER2 positive disease had the lowest 10-year RFS. In the Netherlands, breast cancer subtypes are important predictors for 10-year recurrence rates. Knowledge on recurrence and survival rates according to these different subtypes, in combination with other prognostic factors, can support patient-tailored treatment and individualised follow-up.

KW - breast cancer subtypes

KW - breast cancer

KW - recurrence

KW - 10-year follow-up

KW - population-based

KW - hazard

KW - MOLECULAR SUBTYPES

KW - REGIONAL RECURRENCE

KW - HISTOLOGICAL GRADE

KW - ENDOCRINE THERAPY

KW - EXPRESSION

KW - RECEPTOR

KW - IMPACT

KW - RECOMMENDATIONS

KW - CLASSIFICATION

KW - PATTERNS

U2 - 10.1002/ijc.31914

DO - 10.1002/ijc.31914

M3 - Article

VL - 144

SP - 263

EP - 272

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 2

ER -

ID: 91019026