Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based studyvan Maaren, M. C., de Munck, L., Strobbe, L. J. A., Sonke, G. S., Westenend, P. J., Smidt, M. L., Poortmans, P. M. P. & Siesling, S., 15-Jan-2019, In : International Journal of Cancer. 144, 2, p. 263-272 10 p.
Research output: Contribution to journal › Article › Academic › peer-review
Here we report for the first time the relation between breast cancer subtypes and 10-year recurrence rates and mortality in the Netherlands. All operated women diagnosed with invasive non-metastatic breast cancer in 2005 in the Netherlands were included. Patients were classified into breast cancer subtypes according to ER, PR, HER2 status and grade: luminal A, luminal B, HER2 positive and triple negative. Percentages and hazards of recurrence were compared among subtypes. Adjusted 10-year overall (OS) and recurrence-free survival (RFS) were calculated using multivariable Cox regression. Of 8,062 patients, 4,482 (56%) were luminal A, 2,090 (26%) luminal B, 504 (6%) HER2 positive and 986 (12%) triple negative. Local recurrences (7.5%) and distant metastases (25.6%) occurred most often in HER2 positive disease and the least often in luminal A (3.7% and 9.5%, respectively). Regional recurrences were most often diagnosed in triple negative disease (5.2%), and the least often in luminal A (1.7%). HER2 positive and triple negative subtypes had the highest recurrence rates in the second year, while luminal A and B showed a more continuous pattern over time, with lobular tumours recurring more often. After adjustment for differences in baseline characteristics, triple negative disease showed worse 10-year OS and triple negative and HER2 positive disease had the lowest 10-year RFS. In the Netherlands, breast cancer subtypes are important predictors for 10-year recurrence rates. Knowledge on recurrence and survival rates according to these different subtypes, in combination with other prognostic factors, can support patient-tailored treatment and individualised follow-up.
|Number of pages||10|
|Journal||International Journal of Cancer|
|Publication status||Published - 15-Jan-2019|
- breast cancer subtypes, breast cancer, recurrence, 10-year follow-up, population-based, hazard, MOLECULAR SUBTYPES, REGIONAL RECURRENCE, HISTOLOGICAL GRADE, ENDOCRINE THERAPY, EXPRESSION, RECEPTOR, IMPACT, RECOMMENDATIONS, CLASSIFICATION, PATTERNS