Publication

Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library

Nowak, P., Colomb-Delsuc, M., Otto, S. & Li, J., 2-Sep-2015, In : Journal of the American Chemical Society. 137, 34, p. 10965-10969 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Nowak, P., Colomb-Delsuc, M., Otto, S., & Li, J. (2015). Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library. Journal of the American Chemical Society, 137(34), 10965-10969. https://doi.org/10.1021/jacs.5b04380

Author

Nowak, Piotr ; Colomb-Delsuc, Mathieu ; Otto, Sijbren ; Li, Jianwei. / Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library. In: Journal of the American Chemical Society. 2015 ; Vol. 137, No. 34. pp. 10965-10969.

Harvard

Nowak, P, Colomb-Delsuc, M, Otto, S & Li, J 2015, 'Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library', Journal of the American Chemical Society, vol. 137, no. 34, pp. 10965-10969. https://doi.org/10.1021/jacs.5b04380

Standard

Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library. / Nowak, Piotr; Colomb-Delsuc, Mathieu; Otto, Sijbren; Li, Jianwei.

In: Journal of the American Chemical Society, Vol. 137, No. 34, 02.09.2015, p. 10965-10969.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Nowak P, Colomb-Delsuc M, Otto S, Li J. Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library. Journal of the American Chemical Society. 2015 Sep 2;137(34):10965-10969. https://doi.org/10.1021/jacs.5b04380


BibTeX

@article{92c75bfe7ba6470bb5f50934fc262208,
title = "Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library",
abstract = "Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.",
author = "Piotr Nowak and Mathieu Colomb-Delsuc and Sijbren Otto and Jianwei Li",
year = "2015",
month = "9",
day = "2",
doi = "10.1021/jacs.5b04380",
language = "English",
volume = "137",
pages = "10965--10969",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "AMER CHEMICAL SOC",
number = "34",

}

RIS

TY - JOUR

T1 - Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library

AU - Nowak, Piotr

AU - Colomb-Delsuc, Mathieu

AU - Otto, Sijbren

AU - Li, Jianwei

PY - 2015/9/2

Y1 - 2015/9/2

N2 - Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.

AB - Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.

U2 - 10.1021/jacs.5b04380

DO - 10.1021/jacs.5b04380

M3 - Article

VL - 137

SP - 10965

EP - 10969

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 34

ER -

ID: 24178179