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Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library

Nowak, P., Colomb-Delsuc, M., Otto, S. & Li, J., 2-Sep-2015, In : Journal of the American Chemical Society. 137, 34, p. 10965-10969 5 p.

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  • Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial

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DOI

Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.

Original languageEnglish
Pages (from-to)10965-10969
Number of pages5
JournalJournal of the American Chemical Society
Volume137
Issue number34
Publication statusPublished - 2-Sep-2015

ID: 24178179