Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial LibraryNowak, P., Colomb-Delsuc, M., Otto, S. & Li, J., 2-Sep-2015, In : Journal of the American Chemical Society. 137, 34, p. 10965-10969 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
|Number of pages||5|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 2-Sep-2015|