Publication

Telomere biology in healthy aging and disease

Oeseburg, H., de Boer, R. A., van Gilst, W. H. & van der Harst, P. Jan-2010 In : Pflugers archiv-European journal of physiology. 459, 2, p. 259-268 10 p.

Research output: Scientific - peer-reviewLiterature review

APA

Oeseburg, H., de Boer, R. A., van Gilst, W. H., & van der Harst, P. (2010). Telomere biology in healthy aging and disease. Pflugers archiv-European journal of physiology, 459(2), 259-268. DOI: 10.1007/s00424-009-0728-1

Author

Oeseburg, Hisko ; de Boer, Rudolf A. ; van Gilst, Wiek H. ; van der Harst, Pim. / Telomere biology in healthy aging and disease. In: Pflugers archiv-European journal of physiology. 2010 ; Vol. 459, No. 2. pp. 259-268

Harvard

Oeseburg, H, de Boer, RA, van Gilst, WH & van der Harst, P 2010, 'Telomere biology in healthy aging and disease' Pflugers archiv-European journal of physiology, vol 459, no. 2, pp. 259-268. DOI: 10.1007/s00424-009-0728-1

Standard

Telomere biology in healthy aging and disease. / Oeseburg, Hisko; de Boer, Rudolf A.; van Gilst, Wiek H.; van der Harst, Pim.

In: Pflugers archiv-European journal of physiology, Vol. 459, No. 2, 01.2010, p. 259-268.

Research output: Scientific - peer-reviewLiterature review

Vancouver

Oeseburg H, de Boer RA, van Gilst WH, van der Harst P. Telomere biology in healthy aging and disease. Pflugers archiv-European journal of physiology. 2010 Jan;459(2):259-268. Available from, DOI: 10.1007/s00424-009-0728-1


BibTeX

@article{31f199b478734a15bb38608b2c221108,
title = "Telomere biology in healthy aging and disease",
abstract = "Aging is a biological process that affects most cells, organisms and species. Telomeres have been postulated as a universal biological clock that shortens in parallel with aging in cells. Telomeres are located at the end of the chromosomes and consist of an evolutionary conserved repetitive nucleotide sequence ranging in length from a few hundred base pairs in yeast till several kilo base pairs in vertebrates. Telomeres associate with shelterin proteins and form a complex protecting the chromosomal deoxyribonucleic acid (DNA) from recognition by the DNA damage-repair system. Due to the {"}end-replication problem{"} telomeres shorten with each mitotic cycle resulting in cumulative telomere attrition during aging. When telomeres reach a critical length the cell will not further undergo cell divisions and become senescent or otherwise dysfunctional. Telomere shortening has not only been linked to aging but also to several age associated diseases, including tumorigenesis, coronary artery disease, and heart failure. In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases.",
keywords = "Aging, Tumor, Heart, Apoptosis, Cell death, CORONARY-ARTERY-DISEASE, CHRONIC HEART-FAILURE, IMPROVES CARDIAC-FUNCTION, HEMATOPOIETIC STEM-CELLS, SENESCENT HUMAN-CELLS, C-REACTIVE PROTEIN, LONG-LIVED BIRDS, CARDIOVASCULAR-DISEASE, ANGIOTENSIN-II, REPLICATIVE SENESCENCE",
author = "Hisko Oeseburg and {de Boer}, {Rudolf A.} and {van Gilst}, {Wiek H.} and {van der Harst}, Pim",
year = "2010",
month = "1",
doi = "10.1007/s00424-009-0728-1",
volume = "459",
pages = "259--268",
journal = "Pflügers Archiv : European Journal of Physiology",
issn = "0031-6768",
number = "2",

}

RIS

TY - JOUR

T1 - Telomere biology in healthy aging and disease

AU - Oeseburg,Hisko

AU - de Boer,Rudolf A.

AU - van Gilst,Wiek H.

AU - van der Harst,Pim

PY - 2010/1

Y1 - 2010/1

N2 - Aging is a biological process that affects most cells, organisms and species. Telomeres have been postulated as a universal biological clock that shortens in parallel with aging in cells. Telomeres are located at the end of the chromosomes and consist of an evolutionary conserved repetitive nucleotide sequence ranging in length from a few hundred base pairs in yeast till several kilo base pairs in vertebrates. Telomeres associate with shelterin proteins and form a complex protecting the chromosomal deoxyribonucleic acid (DNA) from recognition by the DNA damage-repair system. Due to the "end-replication problem" telomeres shorten with each mitotic cycle resulting in cumulative telomere attrition during aging. When telomeres reach a critical length the cell will not further undergo cell divisions and become senescent or otherwise dysfunctional. Telomere shortening has not only been linked to aging but also to several age associated diseases, including tumorigenesis, coronary artery disease, and heart failure. In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases.

AB - Aging is a biological process that affects most cells, organisms and species. Telomeres have been postulated as a universal biological clock that shortens in parallel with aging in cells. Telomeres are located at the end of the chromosomes and consist of an evolutionary conserved repetitive nucleotide sequence ranging in length from a few hundred base pairs in yeast till several kilo base pairs in vertebrates. Telomeres associate with shelterin proteins and form a complex protecting the chromosomal deoxyribonucleic acid (DNA) from recognition by the DNA damage-repair system. Due to the "end-replication problem" telomeres shorten with each mitotic cycle resulting in cumulative telomere attrition during aging. When telomeres reach a critical length the cell will not further undergo cell divisions and become senescent or otherwise dysfunctional. Telomere shortening has not only been linked to aging but also to several age associated diseases, including tumorigenesis, coronary artery disease, and heart failure. In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases.

KW - Aging

KW - Tumor

KW - Heart

KW - Apoptosis

KW - Cell death

KW - CORONARY-ARTERY-DISEASE

KW - CHRONIC HEART-FAILURE

KW - IMPROVES CARDIAC-FUNCTION

KW - HEMATOPOIETIC STEM-CELLS

KW - SENESCENT HUMAN-CELLS

KW - C-REACTIVE PROTEIN

KW - LONG-LIVED BIRDS

KW - CARDIOVASCULAR-DISEASE

KW - ANGIOTENSIN-II

KW - REPLICATIVE SENESCENCE

U2 - 10.1007/s00424-009-0728-1

DO - 10.1007/s00424-009-0728-1

M3 - Literature review

VL - 459

SP - 259

EP - 268

JO - Pflügers Archiv : European Journal of Physiology

T2 - Pflügers Archiv : European Journal of Physiology

JF - Pflügers Archiv : European Journal of Physiology

SN - 0031-6768

IS - 2

ER -

ID: 5010184