Publication

Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver

Melgert, BN., Lebbe, C., Wartna, E., Molema, G., Poelstra, K., Albrecht, C., Reichen, J. & Meijer, DKF., 1997, CELLS OF THE HEPATIC SINUSOID, VOL 6. Wisse, E., Knook, DL. & Balabaud, C. (eds.). LEIDEN: The Kupffer Cell Foundation, p. 389-390 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

APA

Melgert, BN., Lebbe, C., Wartna, E., Molema, G., Poelstra, K., Albrecht, C., Reichen, J., & Meijer, DKF. (1997). Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver. In E. Wisse, DL. Knook, & C. Balabaud (Eds.), CELLS OF THE HEPATIC SINUSOID, VOL 6 (pp. 389-390). The Kupffer Cell Foundation.

Author

Melgert, BN ; Lebbe, C ; Wartna, E ; Molema, G ; Poelstra, K ; Albrecht, C ; Reichen, J ; Meijer, DKF. / Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver. CELLS OF THE HEPATIC SINUSOID, VOL 6. editor / E Wisse ; DL Knook ; C Balabaud. LEIDEN : The Kupffer Cell Foundation, 1997. pp. 389-390

Harvard

Melgert, BN, Lebbe, C, Wartna, E, Molema, G, Poelstra, K, Albrecht, C, Reichen, J & Meijer, DKF 1997, Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver. in E Wisse, DL Knook & C Balabaud (eds), CELLS OF THE HEPATIC SINUSOID, VOL 6. The Kupffer Cell Foundation, LEIDEN, pp. 389-390, 8th International Symposium on the Cells of the Hepatic Sinusoid, France, 01/09/1996.

Standard

Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver. / Melgert, BN; Lebbe, C; Wartna, E; Molema, G; Poelstra, K; Albrecht, C; Reichen, J; Meijer, DKF.

CELLS OF THE HEPATIC SINUSOID, VOL 6. ed. / E Wisse; DL Knook; C Balabaud. LEIDEN : The Kupffer Cell Foundation, 1997. p. 389-390.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Vancouver

Melgert BN, Lebbe C, Wartna E, Molema G, Poelstra K, Albrecht C et al. Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver. In Wisse E, Knook DL, Balabaud C, editors, CELLS OF THE HEPATIC SINUSOID, VOL 6. LEIDEN: The Kupffer Cell Foundation. 1997. p. 389-390


BibTeX

@inproceedings{2152177a30454987aac609f6c967a792,
title = "Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver",
abstract = "We have coupled the anti-inflammatory drug naproxen (Nap) covalently to human serum albumin (HSA) to deliver this drug selectively to non parenchymal cell types of the liver during endotoxin induced hepatic inflammation. Liver endothelial cells and Kupffer cells play an important role in the pathogenesis of acute and chronic inflammatory liver diseases. Targeting Nap to these cells might increase the efficacy of this drug in the treatment of these diseases and reduce its side effects. During acute inflammation in male rats, induced by endotoxin, livers showed an increased uptake of Nap when coupled to HSA as compared to free Nap. 3 hours after administering 24 mg/kg Nap(23)-HSA 28% of the dose was found in the liver versus 1.1% of a therapeutic dose of 50 mg/kg Nap (pIn conclusion, during endotoxin induced inflammation the distribution of Nap as a Nap(23)-HSA conjugate to the liver is enhanced as compared to free Nap. Moreover, Nap liberated from the albumin carrier by proteolytic degradation exhibits a longer residence time in the liver, as compared to free Nap.",
author = "BN Melgert and C Lebbe and E Wartna and G Molema and K Poelstra and C Albrecht and J Reichen and DKF Meijer",
year = "1997",
language = "English",
isbn = "90-803856-1-1",
pages = "389--390",
editor = "E Wisse and DL Knook and C Balabaud",
booktitle = "CELLS OF THE HEPATIC SINUSOID, VOL 6",
publisher = "The Kupffer Cell Foundation",
note = "8th International Symposium on the Cells of the Hepatic Sinusoid ; Conference date: 01-09-1996 Through 05-09-1996",

}

RIS

TY - GEN

T1 - Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver

AU - Melgert, BN

AU - Lebbe, C

AU - Wartna, E

AU - Molema, G

AU - Poelstra, K

AU - Albrecht, C

AU - Reichen, J

AU - Meijer, DKF

PY - 1997

Y1 - 1997

N2 - We have coupled the anti-inflammatory drug naproxen (Nap) covalently to human serum albumin (HSA) to deliver this drug selectively to non parenchymal cell types of the liver during endotoxin induced hepatic inflammation. Liver endothelial cells and Kupffer cells play an important role in the pathogenesis of acute and chronic inflammatory liver diseases. Targeting Nap to these cells might increase the efficacy of this drug in the treatment of these diseases and reduce its side effects. During acute inflammation in male rats, induced by endotoxin, livers showed an increased uptake of Nap when coupled to HSA as compared to free Nap. 3 hours after administering 24 mg/kg Nap(23)-HSA 28% of the dose was found in the liver versus 1.1% of a therapeutic dose of 50 mg/kg Nap (pIn conclusion, during endotoxin induced inflammation the distribution of Nap as a Nap(23)-HSA conjugate to the liver is enhanced as compared to free Nap. Moreover, Nap liberated from the albumin carrier by proteolytic degradation exhibits a longer residence time in the liver, as compared to free Nap.

AB - We have coupled the anti-inflammatory drug naproxen (Nap) covalently to human serum albumin (HSA) to deliver this drug selectively to non parenchymal cell types of the liver during endotoxin induced hepatic inflammation. Liver endothelial cells and Kupffer cells play an important role in the pathogenesis of acute and chronic inflammatory liver diseases. Targeting Nap to these cells might increase the efficacy of this drug in the treatment of these diseases and reduce its side effects. During acute inflammation in male rats, induced by endotoxin, livers showed an increased uptake of Nap when coupled to HSA as compared to free Nap. 3 hours after administering 24 mg/kg Nap(23)-HSA 28% of the dose was found in the liver versus 1.1% of a therapeutic dose of 50 mg/kg Nap (pIn conclusion, during endotoxin induced inflammation the distribution of Nap as a Nap(23)-HSA conjugate to the liver is enhanced as compared to free Nap. Moreover, Nap liberated from the albumin carrier by proteolytic degradation exhibits a longer residence time in the liver, as compared to free Nap.

M3 - Conference contribution

SN - 90-803856-1-1

SP - 389

EP - 390

BT - CELLS OF THE HEPATIC SINUSOID, VOL 6

A2 - Wisse, E

A2 - Knook, DL

A2 - Balabaud, C

PB - The Kupffer Cell Foundation

CY - LEIDEN

T2 - 8th International Symposium on the Cells of the Hepatic Sinusoid

Y2 - 1 September 1996 through 5 September 1996

ER -

ID: 3688334