Publication

Targeting iron metabolism in drug discovery and delivery

Crielaard, B. J., Lammers, T. & Rivella, S., Jun-2017, In : Nature Reviews Drug Discovery. 16, 6, p. 400-423 24 p.

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DOI

Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and neurodegenerative diseases, have recently been linked to deregulated iron homeostasis. Consequently, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments for these diseases. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents are likely to have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are currently available.

Original languageEnglish
Pages (from-to)400-423
Number of pages24
JournalNature Reviews Drug Discovery
Volume16
Issue number6
Publication statusPublished - Jun-2017

    Keywords

  • BONE MORPHOGENETIC PROTEIN, METAL TRANSPORTER 1, HEMOGLOBIN SCAVENGER RECEPTOR, HUMAN HEPATOMA-CELLS, AUTOSOMAL-DOMINANT HEMOCHROMATOSIS, AMYOTROPHIC-LATERAL-SCLEROSIS, HYDROXYLASE DOMAIN PROTEIN-2, TUMOR-ASSOCIATED MACROPHAGES, REPULSIVE GUIDANCE MOLECULE, BETA-THALASSEMIA-INTERMEDIA

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