Targeting iron metabolism in drug discovery and deliveryCrielaard, B. J., Lammers, T. & Rivella, S., Jun-2017, In : Nature Reviews Drug Discovery. 16, 6, p. 400-423 24 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and neurodegenerative diseases, have recently been linked to deregulated iron homeostasis. Consequently, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments for these diseases. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents are likely to have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are currently available.
|Number of pages||24|
|Journal||Nature Reviews Drug Discovery|
|Publication status||Published - Jun-2017|
- BONE MORPHOGENETIC PROTEIN, METAL TRANSPORTER 1, HEMOGLOBIN SCAVENGER RECEPTOR, HUMAN HEPATOMA-CELLS, AUTOSOMAL-DOMINANT HEMOCHROMATOSIS, AMYOTROPHIC-LATERAL-SCLEROSIS, HYDROXYLASE DOMAIN PROTEIN-2, TUMOR-ASSOCIATED MACROPHAGES, REPULSIVE GUIDANCE MOLECULE, BETA-THALASSEMIA-INTERMEDIA