Publication
Targeting FPR1 and CXCR4 in cancer and the contribution of the tumor microenvironment
Boer, J., 2015, [Groningen]: University of Groningen. 213 p.Research output: Thesis › Thesis fully internal (DIV)

Documents
- Chapter 1
Final publisher's version, 127 KB, PDF document
- Title and contents
Final publisher's version, 192 KB, PDF document
- Chapter 2
Final publisher's version, 280 KB, PDF document
- Chapter 3
Final publisher's version, 316 KB, PDF document
- Chapter 4
Final publisher's version, 593 KB, PDF document
- Chapter 5
Final publisher's version, 542 KB, PDF document
- Chapter 6
Final publisher's version, 1.05 MB, PDF document
- Chapter 7
Final publisher's version, 525 KB, PDF document
- Chapter 8
Final publisher's version, 182 KB, PDF document
- Chapter 9
Final publisher's version, 128 KB, PDF document
- Chapter 10
Final publisher's version, 181 KB, PDF document
- Complete thesis
Final publisher's version, 2.77 MB, PDF document
- Propositions
Final publisher's version, 547 KB, PDF document
From laboratory research it became evident that both receptors are involved in the migration and possible dissemination of tumor cells, which migrate towards their ligands present in the microenvironment. The ligands for FPR1 are formyl-methionil-leucine-lysine-isoleucine-valine (fMLKLIV) and formyl-methionil-methionil-tyrosine-alanine-leucine-phenylalanine (fMMYALF), which are released when unregulated cell death occurs. Jennifer Boer used the chemotaxis inhibitory protein of S. aureus (CHIPS), in order to inhibit the migration of FPR1-positive tumor cells. In a preclinical setting the use of this bacterial derived protein led to a slight survival improvement. When CXCR4 is activated by its ligand CXCL12, the receptor contributes to tumor cell mobility but also to therapy resistance mediated by the tumor microenvironment. The CXCR4 inhibitor AMD3100 transiently sensitizes prostate cancer cells to radiation therapy but eventually leads to an increase of circulating tumor cells. According to Jennifer Boer this is an important aspect that should be taken in consideration when designing future clinical trials that involve the use of CXCR4 inhibitors. She concludes that therapies targeting FPR1 and CXCR4 may contribute to the development of new cancer treatments.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution | |
Supervisors/Advisors |
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Award date | 15-Jun-2015 |
Place of Publication | [Groningen] |
Publisher | |
Print ISBNs | 978-90-367-7914-2 |
Electronic ISBNs | 978-90-367-7919-7 |
Publication status | Published - 2015 |
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