Publication

Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets

Nienhuis, H. H., Gaykema, S. B. M., Timmer-Bosscha, H., Jalving, M., Brouwers, A. H., Lub-de Hooge, M. N., van der Vegt, B., Overmoyer, B., de Vries, E. G. E. & Schroder, C. P., Mar-2015, In : Pharmacology & Therapeutics. 147, p. 63-79 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Nienhuis, H. H., Gaykema, S. B. M., Timmer-Bosscha, H., Jalving, M., Brouwers, A. H., Lub-de Hooge, M. N., ... Schroder, C. P. (2015). Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets. Pharmacology & Therapeutics, 147, 63-79. https://doi.org/10.1016/j.pharmthera.2014.11.004

Author

Nienhuis, H. H. ; Gaykema, S. B. M. ; Timmer-Bosscha, H. ; Jalving, M. ; Brouwers, A. H. ; Lub-de Hooge, M. N. ; van der Vegt, B. ; Overmoyer, B. ; de Vries, E. G. E. ; Schroder, C. P. / Targeting breast cancer through its microenvironment : Current status of preclinical and clinical research in finding relevant targets. In: Pharmacology & Therapeutics. 2015 ; Vol. 147. pp. 63-79.

Harvard

Nienhuis, HH, Gaykema, SBM, Timmer-Bosscha, H, Jalving, M, Brouwers, AH, Lub-de Hooge, MN, van der Vegt, B, Overmoyer, B, de Vries, EGE & Schroder, CP 2015, 'Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets', Pharmacology & Therapeutics, vol. 147, pp. 63-79. https://doi.org/10.1016/j.pharmthera.2014.11.004

Standard

Targeting breast cancer through its microenvironment : Current status of preclinical and clinical research in finding relevant targets. / Nienhuis, H. H.; Gaykema, S. B. M.; Timmer-Bosscha, H.; Jalving, M.; Brouwers, A. H.; Lub-de Hooge, M. N.; van der Vegt, B.; Overmoyer, B.; de Vries, E. G. E.; Schroder, C. P.

In: Pharmacology & Therapeutics, Vol. 147, 03.2015, p. 63-79.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Nienhuis HH, Gaykema SBM, Timmer-Bosscha H, Jalving M, Brouwers AH, Lub-de Hooge MN et al. Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets. Pharmacology & Therapeutics. 2015 Mar;147:63-79. https://doi.org/10.1016/j.pharmthera.2014.11.004


BibTeX

@article{36cb99c44bfc49a2a66025a264d443e4,
title = "Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets",
abstract = "It is increasingly evident that not only breast cancer cells, but also the tissue embedding these cells: the tumor microenvironment, plays an important role in tumor progression, metastasis formation and treatment sensitivity. This review focuses on the current knowledge of processes by which the microenvironment affects breast cancer, including formation of the metastatic niche, metabolic stimulation, stimulation of tumor cell migration, immune modulation, angiogenesis and matrix remodeling. The number of drugs targeting key factors in these processes is expanding, and the available clinical data is increasing. Therefore current strategies for intervention and prediction of treatment response are outlined. At present, targeting the formation of the metastatic niche and metabolic stimulation by the breast cancer microenvironment, are already showing clinical efficacy. Intervening in the stimulation of tumor cell migration and immune modulation by the microenvironment upcoming fields of great research interest. In contrast, targeting microenvironmental angiogenesis or matrix remodeling appears to be of limited clinical relevance in breast cancer treatment so far. Further research is warranted to optimize intervention strategies and develop predictive tests for the relevance of targeting involved factors within the microenvironment in order to optimally personalize breast cancer treatment. (C) 2014 Elsevier Inc. All rights reserved.",
keywords = "Microenvironment, Breast cancer, Targeted therapy, Biomarkers, Metastasis, Metabolism, ENDOTHELIAL GROWTH-FACTOR, BODY-MASS INDEX, TYROSINE KINASE INHIBITOR, MATRIX-METALLOPROTEINASE INHIBITORS, POSITRON-EMISSION-TOMOGRAPHY, TUMOR-ASSOCIATED MACROPHAGES, MAMMARY-GLAND DEVELOPMENT, EPITHELIAL-MESENCHYMAL TRANSITION, BEVACIZUMAB-CONTAINING THERAPY, ADJUVANT ENDOCRINE THERAPY",
author = "Nienhuis, {H. H.} and Gaykema, {S. B. M.} and H. Timmer-Bosscha and M. Jalving and Brouwers, {A. H.} and {Lub-de Hooge}, {M. N.} and {van der Vegt}, B. and B. Overmoyer and {de Vries}, {E. G. E.} and Schroder, {C. P.}",
note = "Copyright {\circledC} 2014 Elsevier Inc. All rights reserved.",
year = "2015",
month = "3",
doi = "10.1016/j.pharmthera.2014.11.004",
language = "English",
volume = "147",
pages = "63--79",
journal = "Pharmacology & Therapeutics",
issn = "0163-7258",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Targeting breast cancer through its microenvironment

T2 - Current status of preclinical and clinical research in finding relevant targets

AU - Nienhuis, H. H.

AU - Gaykema, S. B. M.

AU - Timmer-Bosscha, H.

AU - Jalving, M.

AU - Brouwers, A. H.

AU - Lub-de Hooge, M. N.

AU - van der Vegt, B.

AU - Overmoyer, B.

AU - de Vries, E. G. E.

AU - Schroder, C. P.

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2015/3

Y1 - 2015/3

N2 - It is increasingly evident that not only breast cancer cells, but also the tissue embedding these cells: the tumor microenvironment, plays an important role in tumor progression, metastasis formation and treatment sensitivity. This review focuses on the current knowledge of processes by which the microenvironment affects breast cancer, including formation of the metastatic niche, metabolic stimulation, stimulation of tumor cell migration, immune modulation, angiogenesis and matrix remodeling. The number of drugs targeting key factors in these processes is expanding, and the available clinical data is increasing. Therefore current strategies for intervention and prediction of treatment response are outlined. At present, targeting the formation of the metastatic niche and metabolic stimulation by the breast cancer microenvironment, are already showing clinical efficacy. Intervening in the stimulation of tumor cell migration and immune modulation by the microenvironment upcoming fields of great research interest. In contrast, targeting microenvironmental angiogenesis or matrix remodeling appears to be of limited clinical relevance in breast cancer treatment so far. Further research is warranted to optimize intervention strategies and develop predictive tests for the relevance of targeting involved factors within the microenvironment in order to optimally personalize breast cancer treatment. (C) 2014 Elsevier Inc. All rights reserved.

AB - It is increasingly evident that not only breast cancer cells, but also the tissue embedding these cells: the tumor microenvironment, plays an important role in tumor progression, metastasis formation and treatment sensitivity. This review focuses on the current knowledge of processes by which the microenvironment affects breast cancer, including formation of the metastatic niche, metabolic stimulation, stimulation of tumor cell migration, immune modulation, angiogenesis and matrix remodeling. The number of drugs targeting key factors in these processes is expanding, and the available clinical data is increasing. Therefore current strategies for intervention and prediction of treatment response are outlined. At present, targeting the formation of the metastatic niche and metabolic stimulation by the breast cancer microenvironment, are already showing clinical efficacy. Intervening in the stimulation of tumor cell migration and immune modulation by the microenvironment upcoming fields of great research interest. In contrast, targeting microenvironmental angiogenesis or matrix remodeling appears to be of limited clinical relevance in breast cancer treatment so far. Further research is warranted to optimize intervention strategies and develop predictive tests for the relevance of targeting involved factors within the microenvironment in order to optimally personalize breast cancer treatment. (C) 2014 Elsevier Inc. All rights reserved.

KW - Microenvironment

KW - Breast cancer

KW - Targeted therapy

KW - Biomarkers

KW - Metastasis

KW - Metabolism

KW - ENDOTHELIAL GROWTH-FACTOR

KW - BODY-MASS INDEX

KW - TYROSINE KINASE INHIBITOR

KW - MATRIX-METALLOPROTEINASE INHIBITORS

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - TUMOR-ASSOCIATED MACROPHAGES

KW - MAMMARY-GLAND DEVELOPMENT

KW - EPITHELIAL-MESENCHYMAL TRANSITION

KW - BEVACIZUMAB-CONTAINING THERAPY

KW - ADJUVANT ENDOCRINE THERAPY

U2 - 10.1016/j.pharmthera.2014.11.004

DO - 10.1016/j.pharmthera.2014.11.004

M3 - Review article

C2 - 25444756

VL - 147

SP - 63

EP - 79

JO - Pharmacology & Therapeutics

JF - Pharmacology & Therapeutics

SN - 0163-7258

ER -

ID: 16438479