Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbiditiesvan den Berg, M. P., Meurs, H. & Gosens, R., Jun-2018, In : Current Opinion in Pharmacology. 40, p. 126-133 8 p.
Research output: Contribution to journal › Article › Academic › peer-review
In the airways, arginase and NOS compete for the common substrate L-arginine. In chronic airway diseases, such as asthma and COPD, elevated arginase expression contributes to airway contractility, hyperresponsiveness, inflammation and remodeling. The disrupted L-arginine homeostasis, through changes in arginase and NOS expression and activity, does not only play a central role in the development of various airways diseases such as asthma or COPD. It possibly also affects L-arginine homeostasis throughout the body contributing to the emergence of co-morbidities. This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection.
|Number of pages||8|
|Journal||Current Opinion in Pharmacology|
|Early online date||2018|
|Publication status||Published - Jun-2018|
- OBSTRUCTIVE SLEEP-APNEA, ASYMMETRIC DIMETHYLARGININE ADMA, T-CELL RESPONSES, ARGININE METABOLISM, PULMONARY-DISEASE, ATOPIC-DERMATITIS, ADIPOSE-TISSUE, DEPRESSED-PATIENTS, ALLERGIC RHINITIS, SYNTHASE ACTIVITY