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Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities

van den Berg, M. P., Meurs, H. & Gosens, R., Jun-2018, In : Current Opinion in Pharmacology. 40, p. 126-133 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

In the airways, arginase and NOS compete for the common substrate L-arginine. In chronic airway diseases, such as asthma and COPD, elevated arginase expression contributes to airway contractility, hyperresponsiveness, inflammation and remodeling. The disrupted L-arginine homeostasis, through changes in arginase and NOS expression and activity, does not only play a central role in the development of various airways diseases such as asthma or COPD. It possibly also affects L-arginine homeostasis throughout the body contributing to the emergence of co-morbidities. This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection.

Original languageEnglish
Pages (from-to)126-133
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume40
Early online date2018
Publication statusPublished - Jun-2018

    Keywords

  • OBSTRUCTIVE SLEEP-APNEA, ASYMMETRIC DIMETHYLARGININE ADMA, T-CELL RESPONSES, ARGININE METABOLISM, PULMONARY-DISEASE, ATOPIC-DERMATITIS, ADIPOSE-TISSUE, DEPRESSED-PATIENTS, ALLERGIC RHINITIS, SYNTHASE ACTIVITY

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