Publication

Targeted imaging of integrins in cancer tissues using photocleavable Ru(ii) polypyridine complexes as mass-tags

Han, J., Sun, J., Song, S., Beljaars, L., Groothuis, G. M. M., Permentier, H., Bischoff, R., Halmos, G. B., Verhoeven, C. J., Amstalden van Hove, E. R., Horvatovich, P. & Casini, A., 4-Jun-2020, In : Chemical communications (Cambridge, England). 56, 44, p. 5941-5944 4 p.

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  • Targeted imaging of integrins in cancer tissuesusing photocleavable Ru(II) polypyridinecomplexes as mass-tags

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DOI

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(ii) polypyridine complexes as mass-tags for imaging of integrins alpha v beta 3 in human cancer tissues.

Original languageEnglish
Pages (from-to)5941-5944
Number of pages4
JournalChemical communications (Cambridge, England)
Volume56
Issue number44
Early online date29-Apr-2020
Publication statusPublished - 4-Jun-2020

    Keywords

  • HIGH-SPATIAL-RESOLUTION, TRANSMISSION GEOMETRY, SPECTROMETRY, RUTHENIUM, ALPHA-V-BETA-3, DESORPTION

ID: 124052041