Publication

Targeted imaging of bacterial infections: advances, hurdles and hopes

van Oosten, M., Hahn, M., Crane, L. M. A., Pleijhuis, R. G., Francis, K. P., van Dijl, J. M. & van Dam, G. M., Nov-2015, In : FEMS Microbiology Reviews. 39, 6, p. 892-916 25 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

van Oosten, M., Hahn, M., Crane, L. M. A., Pleijhuis, R. G., Francis, K. P., van Dijl, J. M., & van Dam, G. M. (2015). Targeted imaging of bacterial infections: advances, hurdles and hopes. FEMS Microbiology Reviews, 39(6), 892-916. https://doi.org/10.1093/femsre/fuv029

Author

van Oosten, Marleen ; Hahn, Markus ; Crane, Lucia M. A. ; Pleijhuis, Rick G. ; Francis, Kevin P. ; van Dijl, Jan Maarten ; van Dam, Gooitzen M. / Targeted imaging of bacterial infections : advances, hurdles and hopes. In: FEMS Microbiology Reviews. 2015 ; Vol. 39, No. 6. pp. 892-916.

Harvard

van Oosten, M, Hahn, M, Crane, LMA, Pleijhuis, RG, Francis, KP, van Dijl, JM & van Dam, GM 2015, 'Targeted imaging of bacterial infections: advances, hurdles and hopes' FEMS Microbiology Reviews, vol. 39, no. 6, pp. 892-916. https://doi.org/10.1093/femsre/fuv029

Standard

Targeted imaging of bacterial infections : advances, hurdles and hopes. / van Oosten, Marleen; Hahn, Markus; Crane, Lucia M. A.; Pleijhuis, Rick G.; Francis, Kevin P.; van Dijl, Jan Maarten; van Dam, Gooitzen M.

In: FEMS Microbiology Reviews, Vol. 39, No. 6, 11.2015, p. 892-916.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

van Oosten M, Hahn M, Crane LMA, Pleijhuis RG, Francis KP, van Dijl JM et al. Targeted imaging of bacterial infections: advances, hurdles and hopes. FEMS Microbiology Reviews. 2015 Nov;39(6):892-916. https://doi.org/10.1093/femsre/fuv029


BibTeX

@article{8903c672bd3746f5bf14f380015aa984,
title = "Targeted imaging of bacterial infections: advances, hurdles and hopes",
abstract = "Bacterial infections represent an increasing problem in modern health care, in particular due to ageing populations and accumulating bacterial resistance to antibiotics. Diagnosis is rarely straightforward and consequently treatment is often delayed or indefinite. Therefore, novel tools that can be clinically implemented are urgently needed to accurately and swiftly diagnose infections. Especially, the direct imaging of infections is an attractive option. The challenge of specifically imaging bacterial infections in vivo can be met by targeting bacteria with an imaging agent. Here we review the current status of targeted imaging of bacterial infections, and we discuss advantages and disadvantages of the different approaches. Indeed, significant progress has been made in this field and the clinical implementation of targeted imaging of bacterial infections seems highly feasible. This was recently highlighted by the use of so-called smart activatable probes and a fluorescently labelled derivative of the antibiotic vancomycin. A major challenge remains the selection of the best imaging probes, and we therefore present a set of target selection criteria for clinical implementation of targeted bacterial imaging. Altogether, we conclude that the spectrum of potential applications for targeted bacterial imaging is enormous, ranging from fundamental research on infectious diseases to diagnostic and therapeutic applications.",
keywords = "imaging, infection, bacteria, tracer, fluorescence, radioisotope, POLYCLONAL HUMAN-IMMUNOGLOBULIN, POSITRON-EMISSION-TOMOGRAPHY, NEAR-INFRARED PHOTOIMMUNOTHERAPY, IN-VIVO EVALUATION, STAPHYLOCOCCUS-AUREUS, PHOTODYNAMIC THERAPY, RABBIT MODEL, HUMAN-IGG, TC-99M-CIPROFLOXACIN SCINTIGRAPHY, ANTIMICROBIAL PEPTIDES",
author = "{van Oosten}, Marleen and Markus Hahn and Crane, {Lucia M. A.} and Pleijhuis, {Rick G.} and Francis, {Kevin P.} and {van Dijl}, {Jan Maarten} and {van Dam}, {Gooitzen M.}",
note = "{\circledC} FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2015",
month = "11",
doi = "10.1093/femsre/fuv029",
language = "English",
volume = "39",
pages = "892--916",
journal = "FEMS Microbiology Reviews",
issn = "0168-6445",
publisher = "Oxford University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Targeted imaging of bacterial infections

T2 - advances, hurdles and hopes

AU - van Oosten, Marleen

AU - Hahn, Markus

AU - Crane, Lucia M. A.

AU - Pleijhuis, Rick G.

AU - Francis, Kevin P.

AU - van Dijl, Jan Maarten

AU - van Dam, Gooitzen M.

N1 - © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2015/11

Y1 - 2015/11

N2 - Bacterial infections represent an increasing problem in modern health care, in particular due to ageing populations and accumulating bacterial resistance to antibiotics. Diagnosis is rarely straightforward and consequently treatment is often delayed or indefinite. Therefore, novel tools that can be clinically implemented are urgently needed to accurately and swiftly diagnose infections. Especially, the direct imaging of infections is an attractive option. The challenge of specifically imaging bacterial infections in vivo can be met by targeting bacteria with an imaging agent. Here we review the current status of targeted imaging of bacterial infections, and we discuss advantages and disadvantages of the different approaches. Indeed, significant progress has been made in this field and the clinical implementation of targeted imaging of bacterial infections seems highly feasible. This was recently highlighted by the use of so-called smart activatable probes and a fluorescently labelled derivative of the antibiotic vancomycin. A major challenge remains the selection of the best imaging probes, and we therefore present a set of target selection criteria for clinical implementation of targeted bacterial imaging. Altogether, we conclude that the spectrum of potential applications for targeted bacterial imaging is enormous, ranging from fundamental research on infectious diseases to diagnostic and therapeutic applications.

AB - Bacterial infections represent an increasing problem in modern health care, in particular due to ageing populations and accumulating bacterial resistance to antibiotics. Diagnosis is rarely straightforward and consequently treatment is often delayed or indefinite. Therefore, novel tools that can be clinically implemented are urgently needed to accurately and swiftly diagnose infections. Especially, the direct imaging of infections is an attractive option. The challenge of specifically imaging bacterial infections in vivo can be met by targeting bacteria with an imaging agent. Here we review the current status of targeted imaging of bacterial infections, and we discuss advantages and disadvantages of the different approaches. Indeed, significant progress has been made in this field and the clinical implementation of targeted imaging of bacterial infections seems highly feasible. This was recently highlighted by the use of so-called smart activatable probes and a fluorescently labelled derivative of the antibiotic vancomycin. A major challenge remains the selection of the best imaging probes, and we therefore present a set of target selection criteria for clinical implementation of targeted bacterial imaging. Altogether, we conclude that the spectrum of potential applications for targeted bacterial imaging is enormous, ranging from fundamental research on infectious diseases to diagnostic and therapeutic applications.

KW - imaging

KW - infection

KW - bacteria

KW - tracer

KW - fluorescence

KW - radioisotope

KW - POLYCLONAL HUMAN-IMMUNOGLOBULIN

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - NEAR-INFRARED PHOTOIMMUNOTHERAPY

KW - IN-VIVO EVALUATION

KW - STAPHYLOCOCCUS-AUREUS

KW - PHOTODYNAMIC THERAPY

KW - RABBIT MODEL

KW - HUMAN-IGG

KW - TC-99M-CIPROFLOXACIN SCINTIGRAPHY

KW - ANTIMICROBIAL PEPTIDES

U2 - 10.1093/femsre/fuv029

DO - 10.1093/femsre/fuv029

M3 - Review article

VL - 39

SP - 892

EP - 916

JO - FEMS Microbiology Reviews

JF - FEMS Microbiology Reviews

SN - 0168-6445

IS - 6

ER -

ID: 21834723