Synthetic Minimal Cell: Self-Reproduction of the Boundary Layer

Exterkate, M. & Driessen, A. J. M., 31-Mar-2019, In : ACS Omega. 4, 3, p. 5293-5303 11 p., 02955.

Research output: Contribution to journalArticleAcademicpeer-review

A critical aspect in the bottom-up construction of a synthetic minimal cell is to develop an entity that is capable of self-reproduction. A key role in this process is the expansion and division of the boundary layer that surrounds the compartment, a process in which content loss has to be avoided and the barrier function maintained. Here, we describe the latest developments regarding self-reproduction of a boundary layer with a focus on the growth and division of phospholipid-based membranes in the context of a synthetic minimal cell.

Original languageEnglish
Article number02955
Pages (from-to)5293-5303
Number of pages11
JournalACS Omega
Issue number3
Publication statusPublished - 31-Mar-2019


  • synthetic biology, minimal cell, SELF-REPRODUCTION

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