Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling ProcedureHeijnen, D., Helbert, H., Luurtsema, G., Elsinga, P. H. & Feringa, B. L., 7-Jun-2019, In : Organic letters. 21, 11, p. 4087-4091 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
The synthesis of functionalized (benz)aldehydes, via a two-step, one-pot procedure, is presented. The method employs a stable aluminum hemiaminal as a tetrahedral intermediate, protecting a latent aldehyde, making it suitable for subsequent cross-coupling with (strong nucleophilic) organometallic reagents, leading to a variety of alkyl and aryl substituted benzaldehydes. This very fast methodology also facilitates the effective synthesis of a 11C radiolabeled aldehyde. Aluminum-ate complexes enable transmetalation of alkyl fragments onto palladium and subsequent cross-coupling.
|Number of pages||5|
|Publication status||Published - 7-Jun-2019|