Publication

Synaptic transmission in the rat dentate gyrus after adrenalectomy

Stienstra, CM., Van der Graaf, F., Bosma, A., Karten, YJG., Hesen, W. & Joels, M., Aug-1998, In : Neuroscience. 85, 4, p. 1061-1071 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Stienstra, CM., Van der Graaf, F., Bosma, A., Karten, YJG., Hesen, W., & Joels, M. (1998). Synaptic transmission in the rat dentate gyrus after adrenalectomy. Neuroscience, 85(4), 1061-1071. https://doi.org/10.1016/S0306-4522(97)00655-6

Author

Stienstra, CM ; Van der Graaf, F ; Bosma, A ; Karten, YJG ; Hesen, W ; Joels, M. / Synaptic transmission in the rat dentate gyrus after adrenalectomy. In: Neuroscience. 1998 ; Vol. 85, No. 4. pp. 1061-1071.

Harvard

Stienstra, CM, Van der Graaf, F, Bosma, A, Karten, YJG, Hesen, W & Joels, M 1998, 'Synaptic transmission in the rat dentate gyrus after adrenalectomy', Neuroscience, vol. 85, no. 4, pp. 1061-1071. https://doi.org/10.1016/S0306-4522(97)00655-6

Standard

Synaptic transmission in the rat dentate gyrus after adrenalectomy. / Stienstra, CM; Van der Graaf, F; Bosma, A; Karten, YJG; Hesen, W; Joels, M.

In: Neuroscience, Vol. 85, No. 4, 08.1998, p. 1061-1071.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Stienstra CM, Van der Graaf F, Bosma A, Karten YJG, Hesen W, Joels M. Synaptic transmission in the rat dentate gyrus after adrenalectomy. Neuroscience. 1998 Aug;85(4):1061-1071. https://doi.org/10.1016/S0306-4522(97)00655-6


BibTeX

@article{7350167c9ef14076a55df3b0f2862c4b,
title = "Synaptic transmission in the rat dentate gyrus after adrenalectomy",
abstract = "Granule cells in the rat hippocampal dentate gyrus contain intracellular receptors for the adrenal hormone corticosterone. Activation of these receptors seems essential for granule cell viability, since removal of the adrenal gland (adrenalectomy) results within three days in apoptotic-like degeneration of. granule cells. In the present study we used extracellular in vitro recording methods to study the synaptic transmission in the dentate gyrus of adrenalectomized animals, in sham-operated controls and adrenalectomized rats treated with a low dose of corticosterone. We found that particularly three days after adrenalectomy orthodromic field responses in the dentate gyrus were reduced in amplitude. Corticosterone-treated rats did not show this impairment of synaptic transmission. Antidromically-evoked field responses were also reduced after adrenalectomy, which indicates that postsynaptic cell properties rather than signal transduction in the synapses are under steroid control. Responses to paired pulse stimulation were only marginally affected, suggesting that interneuronal networks may be less affected by the hormones than the principal cells.These electrophysiological data indicate that adrenalectomy induced apoptotic-like degeneration in the hippocampal dentate gyrus is clearly associated with impaired processing of incoming information. (C) 1998 IBRO. Published by Elsevier Science Ltd.",
keywords = "corticosterone, apoptosis, hippocampus, field potential, electrophysiology, GRANULE CELL DEGENERATION, HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY, PROLONGED STIMULATION, PERFORANT PATH, NERVOUS-SYSTEM, BALB/C MICE, HILAR CELLS, CORTICOSTERONE, RECEPTORS, DEATH",
author = "CM Stienstra and {Van der Graaf}, F and A Bosma and YJG Karten and W Hesen and M Joels",
year = "1998",
month = "8",
doi = "10.1016/S0306-4522(97)00655-6",
language = "English",
volume = "85",
pages = "1061--1071",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",
number = "4",

}

RIS

TY - JOUR

T1 - Synaptic transmission in the rat dentate gyrus after adrenalectomy

AU - Stienstra, CM

AU - Van der Graaf, F

AU - Bosma, A

AU - Karten, YJG

AU - Hesen, W

AU - Joels, M

PY - 1998/8

Y1 - 1998/8

N2 - Granule cells in the rat hippocampal dentate gyrus contain intracellular receptors for the adrenal hormone corticosterone. Activation of these receptors seems essential for granule cell viability, since removal of the adrenal gland (adrenalectomy) results within three days in apoptotic-like degeneration of. granule cells. In the present study we used extracellular in vitro recording methods to study the synaptic transmission in the dentate gyrus of adrenalectomized animals, in sham-operated controls and adrenalectomized rats treated with a low dose of corticosterone. We found that particularly three days after adrenalectomy orthodromic field responses in the dentate gyrus were reduced in amplitude. Corticosterone-treated rats did not show this impairment of synaptic transmission. Antidromically-evoked field responses were also reduced after adrenalectomy, which indicates that postsynaptic cell properties rather than signal transduction in the synapses are under steroid control. Responses to paired pulse stimulation were only marginally affected, suggesting that interneuronal networks may be less affected by the hormones than the principal cells.These electrophysiological data indicate that adrenalectomy induced apoptotic-like degeneration in the hippocampal dentate gyrus is clearly associated with impaired processing of incoming information. (C) 1998 IBRO. Published by Elsevier Science Ltd.

AB - Granule cells in the rat hippocampal dentate gyrus contain intracellular receptors for the adrenal hormone corticosterone. Activation of these receptors seems essential for granule cell viability, since removal of the adrenal gland (adrenalectomy) results within three days in apoptotic-like degeneration of. granule cells. In the present study we used extracellular in vitro recording methods to study the synaptic transmission in the dentate gyrus of adrenalectomized animals, in sham-operated controls and adrenalectomized rats treated with a low dose of corticosterone. We found that particularly three days after adrenalectomy orthodromic field responses in the dentate gyrus were reduced in amplitude. Corticosterone-treated rats did not show this impairment of synaptic transmission. Antidromically-evoked field responses were also reduced after adrenalectomy, which indicates that postsynaptic cell properties rather than signal transduction in the synapses are under steroid control. Responses to paired pulse stimulation were only marginally affected, suggesting that interneuronal networks may be less affected by the hormones than the principal cells.These electrophysiological data indicate that adrenalectomy induced apoptotic-like degeneration in the hippocampal dentate gyrus is clearly associated with impaired processing of incoming information. (C) 1998 IBRO. Published by Elsevier Science Ltd.

KW - corticosterone

KW - apoptosis

KW - hippocampus

KW - field potential

KW - electrophysiology

KW - GRANULE CELL DEGENERATION

KW - HIPPOCAMPAL SLICE ELECTROPHYSIOLOGY

KW - PROLONGED STIMULATION

KW - PERFORANT PATH

KW - NERVOUS-SYSTEM

KW - BALB/C MICE

KW - HILAR CELLS

KW - CORTICOSTERONE

KW - RECEPTORS

KW - DEATH

U2 - 10.1016/S0306-4522(97)00655-6

DO - 10.1016/S0306-4522(97)00655-6

M3 - Article

VL - 85

SP - 1061

EP - 1071

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 4

ER -

ID: 65971340