Publication

Symptom Dimensions in OCD: Item-Level Factor Analysis and Heritability Estimates

Katerberg, H., Delucchi, K. L., Stewart, S. E., Lochner, C., Denys, D. A. J. P., Stack, D. E., Andresen, J. M., Grant, J. E., Kim, S. W., Williams, K. A., den Boer, J. A., van Balkom, A. J. L. M., Smit, J. H., van Oppen, P., Polman, A., Jenike, M. A., Stein, D. J., Mathews, C. A. & Cath, D. C., Jul-2010, In : Behavior Genetics. 40, 4, p. 505-517 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

DOI

  • Hilga Katerberg
  • Kevin L. Delucchi
  • S. Evelyn Stewart
  • Christine Lochner
  • Damiaan A. J. P. Denys
  • Denise E. Stack
  • J. Michael Andresen
  • J. E. Grant
  • Suck W. Kim
  • Kyle A. Williams
  • Johan A. den Boer
  • Anton J. L. M. van Balkom
  • Johannes H. Smit
  • Patricia van Oppen
  • Annemiek Polman
  • Michael A. Jenike
  • Dan J. Stein
  • Carol A. Mathews
  • Danielle C. Cath

To reduce the phenotypic heterogeneity of obsessive-compulsive disorder (OCD) for genetic, clinical and translational studies, numerous factor analyses of the Yale-Brown Obsessive Compulsive Scale checklist (YBOCS-CL) have been conducted. Results of these analyses have been inconsistent, likely as a consequence of small sample sizes and variable methodologies. Furthermore, data concerning the heritability of the factors are limited. Item and category-level factor analyses of YBOCS-CL items from 1224 OCD subjects were followed by heritability analyses in 52 OCD-affected multigenerational families. Item-level analyses indicated that a five factor model: (1) taboo, (2) contamination/cleaning, (3) doubts, (4) superstitions/rituals, and (5) symmetry/hoarding provided the best fit, followed by a one-factor solution. All 5 factors as well as the one-factor solution were found to be heritable. Bivariate analyses indicated that the taboo and doubts factor, and the contamination and symmetry/hoarding factor share genetic influences. Contamination and symmetry/hoarding show shared genetic variance with symptom severity. Nearly all factors showed shared environmental variance with each other and with symptom severity. These results support the utility of both OCD diagnosis and symptom dimensions in genetic research and clinical contexts. Both shared and unique genetic influences underlie susceptibility to OCD and its symptom dimensions.

Original languageEnglish
Pages (from-to)505-517
Number of pages13
JournalBehavior Genetics
Volume40
Issue number4
Publication statusPublished - Jul-2010

    Keywords

  • OCD, Factor analysis, Heritability, Symptom dimensions, Y-BOCS, Genetic, Severity, Onset, OBSESSIVE-COMPULSIVE DISORDER, INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW, FACTOR-ANALYZED SYMPTOM, COLLABORATIVE GENETICS, QUANTITATIVE-TRAIT, YBOCS DIMENSIONS, SEX-DIFFERENCES, SIBLING PAIRS, DSM-IV, SCALE

Download statistics

No data available

ID: 5104945