Publication

Sympathetic denervation in patients with ischemic cardiomyopathy and risk on ventricular tachy-arrhythmias. A pilot study

Noordzij, W., Elvan, A., Demirel, F., Jager, P. L., Tio, R. A. & Slart, R. H., Dec-2018, In : Quarterly Journal of Nuclear Medicine and Molecular Imaging. 62, 4, p. 429-435 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

BACKGROUND: Patients with ischemic cardiomyopathy (ICM) are at risk for ventricular arrhythmias and are protected by an implantable cardioverter defibrillator (ICD). Visualization of cardiac sympathetic innervation may play an additional role to left ventricular ejection fraction (LVEF) in identifying those patients who will benefit from ICD therapy. The purpose of this study was to detect the role of sympathetic denervation in the genesis of ventricular arrhythmias in ICM patients.

METHODS: Twenty patients with ICM and LVEF

RESULTS: Mean age was 63 +/- 7.5 years. Mean global retention of [C-11]-mHED was 0.055 +/- 0,012 min(-1), and was not different between the two patient groups: 0.056 +/- 0.011 min(-1) vs. 0.054 +/- 0.013 min(-1) for group A vs. group B, respectively. During follow-up, seven patients developed ventricular arrhythmias, and four patients died. No difference in [C-11]-mHED retention was found between patients with and without ventricular arrhythmia during follow-up. However, size of denervated area was larger in patients who died during follow-up: 10 +/- 1 segments vs. 6 +/- 2 segments, P=0.002.

CONCLUSIONS: Cardiac sympathetic innervation is impaired in patients with ischemic cardiomyopathy. All-cause mortality occurred in those patients with large areas of [C-11]-mHED defect.

Original languageEnglish
Pages (from-to)429-435
Number of pages7
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume62
Issue number4
Publication statusPublished - Dec-2018

    Keywords

  • Defibrillators, implantable, 3-hydroxyephedrine, Innervation, Cardiomyopathies, Arrhythmias, cardiac, CORONARY-ARTERY-DISEASE, POSITRON-EMISSION-TOMOGRAPHY, C-11 HYDROXYEPHEDRINE, MYOCARDIAL-INFARCTION, NEURONAL FUNCTION, INNERVATION, HEART, SESTAMIBI, FLOW

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