Publication

Survival benefit in women with BRCA1 mutation or familial risk in the MRI screening study (MRISC)

Saadatmand, S., Obdeijn, I-M., Rutgers, E. J., Oosterwijk, J. C., Tollenaar, R. A., Woldringh, G. H., Bergers, E., Verhoef, C., Heijnsdijk, E. A., Hooning, M. J., de Koning, H. J. & Tilanus-Linthorst, M. M., 1-Oct-2015, In : International Journal of Cancer. 137, 7, p. 1729-1738 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Survival benefit in women with BRCA1 mutation or familial risk

    Final publisher's version, 357 KB, PDF document

    Request copy

DOI

  • Sepideh Saadatmand
  • Inge-Marie Obdeijn
  • Emiel J. Rutgers
  • Jan C. Oosterwijk
  • Rob A. Tollenaar
  • Gwendolyn H. Woldringh
  • Elisabeth Bergers
  • Cornelis Verhoef
  • Eveline A. Heijnsdijk
  • Maartje J. Hooning
  • Harry J. de Koning
  • Madeleine M. Tilanus-Linthorst

Adding MRI to annual mammography screening improves early breast cancer detection in women with familial risk or BRCA1/2 mutation, but breast cancer specific metastasis free survival (MFS) remains unknown. We compared MFS of patients from the largest prospective MRI Screening Study (MRISC) with 1:1 matched controls. Controls, unscreened if

What's New? Adding MRI to annual mammography screening improves early breast cancer detection in women with familial risk or BRCA1/2 mutation. The impact of MRI screening on metastasis free survival remains unknown, however. For ethical reasons, all of the relevant studies so far have had a non-randomized design. To address this issue, here the authors compare breast cancer patients in the largest prospective MRI Screening Study (MRISC) with controls matched for risk group, year of diagnosis, and age at diagnosis. Annual screening with MRI and mammography improves breast cancer specific metastasis free survival significantly in women with BRCA1 mutation or familial predisposition.

Original languageEnglish
Pages (from-to)1729-1738
Number of pages10
JournalInternational Journal of Cancer
Volume137
Issue number7
Publication statusPublished - 1-Oct-2015

    Keywords

  • BRCA1, BRCA2, breast cancer survival, familial cancer syndromes, screening, HEREDITARY BREAST-CANCER, FOLLOW-UP, RANDOMIZED-TRIALS, MAMMOGRAPHY, CARRIERS, SURVEILLANCE, POPULATION, MASTECTOMY, THERAPY, MULTICENTER

ID: 24101233