Survival and health in liveborn infants with transposition of great arteries--a population-based studyGarne, E., Loane, M. A., Nelen, V., Bakker, M. K., Gener, B., Abramsky, L., Addor, M-C. & Queisser-Luft, A., 2-Apr-2008, In : Congenital heart disease. 2, 3, p. 165-169 5 p.
Research output: Contribution to journal › Article › Academic › peer-review
OBJECTIVE: To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).
DESIGN: Population-based data from 7 European registries of congenital malformations (EUROCAT).
RESULTS: Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.
CONCLUSIONS: In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.
|Number of pages||5|
|Journal||Congenital heart disease|
|Publication status||Published - 2-Apr-2008|
- Cardiac Surgical Procedures, Follow-Up Studies, Humans, Infant Welfare, Infant, Newborn, Live Birth, Prenatal Diagnosis, Prevalence, Prostaglandins/therapeutic use, Registries, Survival Analysis, Transposition of Great Vessels/epidemiology