Survival and health in liveborn infants with transposition of great arteries--a population-based study

Garne, E., Loane, M. A., Nelen, V., Bakker, M. K., Gener, B., Abramsky, L., Addor, M-C. & Queisser-Luft, A., 2-Apr-2008, In : Congenital heart disease. 2, 3, p. 165-169 5 p.

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  • Survival and Health in Liveborn Infants with Transposition of Great Arteries—A Population‐based Study

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  • Ester Garne
  • Maria A Loane
  • Vera Nelen
  • Marian K Bakker
  • Blanca Gener
  • Lenore Abramsky
  • Marie-Claude Addor
  • Annette Queisser-Luft

OBJECTIVE: To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).

DESIGN: Population-based data from 7 European registries of congenital malformations (EUROCAT).

RESULTS: Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10,000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.

CONCLUSIONS: In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalCongenital heart disease
Issue number3
Publication statusPublished - 2-Apr-2008


  • Cardiac Surgical Procedures, Follow-Up Studies, Humans, Infant Welfare, Infant, Newborn, Live Birth, Prenatal Diagnosis, Prevalence, Prostaglandins/therapeutic use, Registries, Survival Analysis, Transposition of Great Vessels/epidemiology

ID: 65922775